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Global trends and prospects in research of artificial cornea over past 20 years: a bibliometric and visualized analysis

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Abstract

Background

Many studies have been focused on the area of the artificial cornea. In our study, a bibliometric analysis was performed on the artificial cornea to identify the global key research fields and trends over the past 20 years.

Methods

Publications about artificial cornea were retrieved and downloaded from the Web of Science Core Collection from 2002 to 2021. CiteSpace and VOSviewer were used to analyze countries, institutions, authors, and related research areas.

Results

A total of 829 eligible publications were analyzed. The USA was the most productive country for the artificial cornea, followed by China and Canada. Harvard University was the most prolific institution in this field. Cornea published most of the studies in this area and Dohlman CH was the most cited author.

Conclusions

Bibliometric analysis in our study first provides a general perspective on the artificial cornea, which can be helpful to further explore the issues in the rapidly developing area.

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Data availability

The data supporting the findings of this study are available from the corresponding author upon reasonable request.

References

  1. Whitcher JP, Srinivasan M, Upadhyay MP (2001) Corneal blindness: a global perspective. Bull World Health Organ 79(3):214–221

    CAS  PubMed  PubMed Central  Google Scholar 

  2. Pascolini D, Mariotti SP (2012) Global estimates of visual impairment: 2010. Br J Ophthalmol 96(5):614–618. https://doi.org/10.1136/bjophthalmol-2011-300539

    Article  PubMed  Google Scholar 

  3. Tan DT, Dart JK, Holland EJ, Kinoshita S (2012) Corneal transplantation. Lancet 379(9827):1749–1761. https://doi.org/10.1016/s0140-6736(12)60437-1

    Article  PubMed  Google Scholar 

  4. Ballouz D, Sawant OB, Hurlbert S, Titus MS, Majmudar PA, Kumar A, Zhou Y, Musch DC, Mian SI (2021) Impact of the COVID-19 pandemic on keratoplasty and corneal eye banking. Cornea 40(8):1018–1023. https://doi.org/10.1097/ico.0000000000002748

    Article  PubMed  PubMed Central  Google Scholar 

  5. Dohlman C (2022) The Boston keratoprosthesis-the first 50 years: some reminiscences. Annu Rev Vis Sci 8:1–32. https://doi.org/10.1146/annurev-vision-100820-021253

    Article  PubMed  Google Scholar 

  6. Fu L, Hollick EJ (2002) Artificial cornea transplantation. StatPearls Publishing, Treasure Island

    Google Scholar 

  7. Avadhanam VS, Smith HE, Liu C (2015) Keratoprostheses for corneal blindness: a review of contemporary devices. Clin Ophthalmol 9:697–720. https://doi.org/10.2147/opth.S27083

    Article  PubMed  PubMed Central  Google Scholar 

  8. Akpek EK, Alkharashi M, Hwang FS, Ng SM, Lindsley K (2014) Artificial corneas versus donor corneas for repeat corneal transplants. Cochrane Database Syst Rev 11(11):Cd009561. https://doi.org/10.1002/14651858.CD009561.pub2

    Article  PubMed  Google Scholar 

  9. Salvador-Culla B, Kolovou PE (2016) Keratoprosthesis: A Review of Recent Advances in the Field. J Funct Biomater. https://doi.org/10.3390/jfb7020013

    Article  PubMed  PubMed Central  Google Scholar 

  10. Dohlman CH, Schneider HA, Doane MG (1974) Prosthokeratoplasty. Am J Ophthalmol 77(5):694–770. https://doi.org/10.1016/0002-9394(74)90534-0

    Article  CAS  PubMed  Google Scholar 

  11. Dohlman CH, Harissi-Dagher M, Khan BF, Sippel K, Aquavella JV, Graney JM (2006) Introduction to the use of the Boston keratoprosthesis. Expert Rev Ophthalmol 1(1):41–48. https://doi.org/10.1586/17469899.1.1.41

    Article  Google Scholar 

  12. Marchi V, Ricci R, Pecorella I, Ciardi A, Di Tondo U (1994) Osteo-odonto-keratoprosthesis. Description of surgical technique with results in 85 patients. Cornea 13(2):125–130

    Article  CAS  PubMed  Google Scholar 

  13. Falcinelli G, Falsini B, Taloni M, Colliardo P, Falcinelli G (2005) Modified osteo-odonto-keratoprosthesis for treatment of corneal blindness: long-term anatomical and functional outcomes in 181 cases. Arch Ophthalmol 123(10):1319–1329. https://doi.org/10.1001/archopht.123.10.1319

    Article  PubMed  Google Scholar 

  14. Huang Y, Yu J, Liu L, Du G, Song J, Guo H (2011) Moscow eye microsurgery complex in Russia keratoprosthesis in Beijing. Ophthalmology 118(1):41–46. https://doi.org/10.1016/j.ophtha.2010.05.019

    Article  PubMed  Google Scholar 

  15. Zou X, Yue WL, Vu HL (2018) Visualization and analysis of mapping knowledge domain of road safety studies. Accid Anal Prev 118:131–145. https://doi.org/10.1016/j.aap.2018.06.010

    Article  PubMed  Google Scholar 

  16. Pekel E, Pekel G (2016) Publication trends in corneal transplantation: a bibliometric analysis. BMC Ophthalmol 16(1):194. https://doi.org/10.1186/s12886-016-0379-x

    Article  PubMed  PubMed Central  Google Scholar 

  17. Leydesdorff L, Carley S, Rafols I (2013) Global maps of science based on the new Web-of-Science categories. Scientometrics 94(2):589–593. https://doi.org/10.1007/s11192-012-0784-8

    Article  PubMed  Google Scholar 

  18. Kundel HL, Polansky M (2003) Measurement of observer agreement. Radiology 228(2):303–308. https://doi.org/10.1148/radiol.2282011860

    Article  PubMed  Google Scholar 

  19. Hirsch JE (2005) An index to quantify an individual’s scientific research output. Proc Natl Acad Sci USA 102(46):16569–16572. https://doi.org/10.1073/pnas.0507655102

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Synnestvedt MB, Chen C, Holmes JH (2005) CiteSpace II: visualization and knowledge discovery in bibliographic databases. AMIA Annu Symp Proc 2005:724–728

    PubMed  PubMed Central  Google Scholar 

  21. van Eck NJ, Waltman L (2010) Software survey: VOSviewer, a computer program for bibliometric mapping. Scientometrics 84(2):523–538. https://doi.org/10.1007/s11192-009-0146-3

    Article  PubMed  Google Scholar 

  22. Lapin M, Tjensvoll K, Oltedal S, Javle M, Smaaland R, Gilje B, Nordgård O (2017) Single-cell mRNA profiling reveals transcriptional heterogeneity among pancreatic circulating tumour cells. BMC Cancer 17(1):390. https://doi.org/10.1186/s12885-017-3385-3

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Fu J, Jiang Z, Hong Y, Liu S, Kong D, Zhong Z, Luo Y (2021) Global scientific research on social participation of older people from 2000 to 2019: a bibliometric analysis. Int J Older People Nurs 16(1):e12349. https://doi.org/10.1111/opn.12349

    Article  PubMed  Google Scholar 

  24. Liu T, Liu X, Li Y, Liu S, Cao C (2021) evolving trends and research hotspots in disaster epidemiology from 1985 to 2020: a bibliometric analysis. Front Public Health 9:720787. https://doi.org/10.3389/fpubh.2021.720787

    Article  PubMed  PubMed Central  Google Scholar 

  25. Jie L, Chen C (2017) Citespace: text mining and visualization in scientific literature, 2nd edn. Capital University of Economics and Business Press, Beijing

    Google Scholar 

  26. Ke L, Lu C, Shen R, Lu T, Ma B, Hua Y (2020) Knowledge mapping of drug-induced liver injury: a scientometric investigation (2010–2019). Front Pharmacol 11:842. https://doi.org/10.3389/fphar.2020.00842

    Article  PubMed  PubMed Central  Google Scholar 

  27. Dohlman CHH-DM, Khan BF et al (2006) Introduction to the use of the Boston keratoprosthesis. Expert Rev Ophthalmol 1:41–48

    Article  Google Scholar 

  28. Ahmad T, Imran M, Ahmad K, Khan M, Baig M, Al-Rifai RH, Al-Omari B (2021) A bibliometric analysis and global trends in fascioliasis research: a neglected tropical disease. Animals (Basel). https://doi.org/10.3390/ani11123385

    Article  PubMed  PubMed Central  Google Scholar 

  29. Yao RQ, Ren C, Wang JN, Wu GS, Zhu XM, Xia ZF, Yao YM (2020) Publication trends of research on sepsis and host immune response during 1999–2019: a 20-year bibliometric analysis. Int J Biol Sci 16(1):27–37. https://doi.org/10.7150/ijbs.37496

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Sweileh WM, Al-Jabi SW, Sawalha AF, AbuTaha AS, Zyoud SH (2016) Bibliometric analysis of medicine-related publications on poverty (2005–2015). Springerplus 5(1):1888. https://doi.org/10.1186/s40064-016-3593-3

    Article  PubMed  PubMed Central  Google Scholar 

  31. Qiu L, Binns CW, Zhao Y, Zhang K, Xie X (2010) Hepatitis B and breastfeeding in Hangzhou, Zhejiang Province, People’s Republic of China. Breastfeed Med 5(3):109–112. https://doi.org/10.1089/bfm.2009.0093

    Article  CAS  PubMed  Google Scholar 

  32. Gondivkar SM, Sarode SC, Gadbail AR, Gondivkar RS, Choudhary N, Patil S (2018) Citation classics in cone beam computed tomography: the 100 top-cited articles. Int J Dent 2018:9423281. https://doi.org/10.1155/2018/9423281

    Article  PubMed  PubMed Central  Google Scholar 

  33. Loonen MPJ, Hage JJ, Kon M (2008) Plastic Surgery Classics: characteristics of 50 top-cited articles in four Plastic Surgery Journals since 1946. Plast Reconstr Surg 121(5):320e-e327. https://doi.org/10.1097/PRS.0b013e31816b13a9

    Article  CAS  PubMed  Google Scholar 

  34. Aldave AJ, Kamal KM, Vo RC, Yu F (2009) The Boston type I keratoprosthesis: improving outcomes and expanding indications. Ophthalmology 116(4):640–651. https://doi.org/10.1016/j.ophtha.2008.12.058

    Article  PubMed  Google Scholar 

  35. Chew HF, Ayres BD, Hammersmith KM, Rapuano CJ, Laibson PR, Myers JS, Jin YP, Cohen EJ (2009) Boston keratoprosthesis outcomes and complications. Cornea 28(9):989–996. https://doi.org/10.1097/ICO.0b013e3181a186dc

    Article  PubMed  Google Scholar 

  36. Wang JH, Gao C, Zhang YS, Wan YZ (2010) Preparation and in vitro characterization of BC/PVA hydrogel composite for its potential use as artificial cornea biomaterial. Mater Sci Eng C Mater Biol Appl 30(1):214–218. https://doi.org/10.1016/j.msec.2009.10.006

    Article  CAS  Google Scholar 

  37. Zerbe BL, Belin MW, Ciolino JB (2006) Results from the multicenter Boston type 1 Keratoprosthesis study. Ophthalmology 113(10):1779.e1–7. https://doi.org/10.1016/j.ophtha.2006.05.015

    Article  PubMed  Google Scholar 

  38. Bradley JC, Hernandez EG, Schwab IR, Mannis MJ (2009) Boston type 1 keratoprosthesis: the University of California Davis experience. Cornea 28(3):321–327. https://doi.org/10.1097/ICO.0b013e31818b8bfa

    Article  PubMed  Google Scholar 

  39. Greiner MA, Li JY, Mannis MJ (2011) Longer-term vision outcomes and complications with the Boston type 1 keratoprosthesis at the University of California. Davis Ophthalmology 118(8):1543–1550. https://doi.org/10.1016/j.ophtha.2010.12.032

    Article  PubMed  Google Scholar 

  40. Sayegh RR, Ang LP, Foster CS, Dohlman CH (2008) The Boston keratoprosthesis in Stevens-Johnson syndrome. Am J Ophthalmol 145(3):438–444. https://doi.org/10.1016/j.ajo.2007.11.002

    Article  PubMed  Google Scholar 

  41. Duan X, Sheardown H (2006) Dendrimer crosslinked collagen as a corneal tissue engineering scaffold: mechanical properties and corneal epithelial cell interactions. Biomaterials 27(26):4608–4617. https://doi.org/10.1016/j.biomaterials.2006.04.022

    Article  CAS  PubMed  Google Scholar 

  42. Ruberti JW, Sinha Roy A, Roberts CJ (2011) Corneal biomechanics and biomaterials. Annu Rev Biomed Eng 13:269–295. https://doi.org/10.1146/annurev-bioeng-070909-105243

    Article  CAS  PubMed  Google Scholar 

  43. Liu C, Paul B, Tandon R, Lee E, Fong K, Mavrikakis I, Herold J, Thorp S, Brittain P, Francis I, Ferrett C, Hull C, Lloyd A, Green D, Franklin V, Tighe B, Fukuda M, Hamada S (2005) The osteo-odonto-keratoprosthesis (OOKP). Semin Ophthalmol 20(2):113–128. https://doi.org/10.1080/08820530590931386

    Article  PubMed  Google Scholar 

  44. Usman MS, Siddiqi TJ, Khan MS, Fatima K, Butler J, Manning WJ, Khosa F (2017) A scientific analysis of the 100 citation classics of valvular heart disease. Am J Cardiol 120(8):1440–1449. https://doi.org/10.1016/j.amjcard.2017.07.035

    Article  PubMed  Google Scholar 

  45. Aksnes DW, Langfeldt L, Wouters P (2019) Citations, citation indicators, and research quality: an overview of basic concepts and theories. SAGE Open 9

  46. Liu XL, Gai SS, Zhou J (2016) Journal impact factor: do the numerator and denominator need correction? PLoS ONE 11(3):e0151414. https://doi.org/10.1371/journal.pone.0151414

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  47. Khan B, Dudenhoefer EJ, Dohlman CH (2001) Keratoprosthesis: an update. Curr Opin Ophthalmol 12(4):282–287. https://doi.org/10.1097/00055735-200108000-00007

    Article  CAS  PubMed  Google Scholar 

  48. Kleinberg J (2003) Bursty and Hierarchical Structure in Streams. Data Min Knowl Disc 7(4):373–397. https://doi.org/10.1023/A:1024940629314

    Article  Google Scholar 

  49. Fernandez AG, Radcliffe NM, Sippel KC, Rosenblatt MI, Sood P, Starr CE, Ciralsky JB, D’Amico DJ, Kiss S (2012) Boston type I keratoprosthesis-donor cornea interface evaluated by high-definition spectral-domain anterior segment optical coherence tomography. Clin Ophthalmol 6:1355–1359. https://doi.org/10.2147/opth.S34787

    Article  PubMed  PubMed Central  Google Scholar 

  50. Kang JJ, Allemann N, Vajaranant TS, Vajaranant T, de la Cruz J, Cortina MS (2013) Anterior segment optical coherence tomography for the quantitative evaluation of the anterior segment following Boston keratoprosthesis. PLoS ONE 8(8):e70673. https://doi.org/10.1371/journal.pone.0070673

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  51. Garcia JP Jr, de la Cruz J, Rosen RB, Buxton DF (2008) Imaging implanted keratoprostheses with anterior-segment optical coherence tomography and ultrasound biomicroscopy. Cornea 27(2):180–188. https://doi.org/10.1097/ICO.0b013e318159bc7d

    Article  PubMed  Google Scholar 

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Funding

This study was supported by the National Natural Science Foundation of China (81160119) and the Key Research and Development Program in Guangxi (AB20238003).

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Authors and Affiliations

  1. Department of Ophthalmology, The First Affiliated Hospital of Guangxi Medical University, Nanning, 513200, Guangxi Zhuang Autonomous Region, China

    Youran Cai, Jiaxin Zhou, Xuyang Xu, Bingbing He & Wenjin Zou

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  1. Youran Cai
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  2. Jiaxin Zhou
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Contributions

YC, JZ and WZ contributed to the design of the study. YC and JZ collected and excluded the data. XX and BH performed the statistical analysis. YC wrote the draft of the manuscript. WZ revised the article. All authors critically reviewed the manuscript and approved the final version.

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Correspondence to Wenjin Zou.

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Cai, Y., Zhou, J., Xu, X. et al. Global trends and prospects in research of artificial cornea over past 20 years: a bibliometric and visualized analysis. Int Ophthalmol 43, 2003–2015 (2023). https://doi.org/10.1007/s10792-022-02600-2

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