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Effect of nutritional supplement based on melatonin on the intraocular pressure in normotensive subjects

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Abstract

Purpose

To evaluate the effect of a new nutritional supplement based on melatonin on the intraocular pressure (IOP) in normotensive subjects.

Patients and methods

A short-term prospective study was designed. Sixty-seven normotensive subjects were recruited. Patients were divided into two groups. The daily group (DG) (n = 18) was instructed to take the supplement between 22:00 and 23:00 (before sleeping) for 3 consecutive days. IOP was measured from 10.00 to 11.00 am the day before treatment and during the 3 days of experiment. The acute group (AG) (n = 49) was instructed to take the supplement after the second measure (11.00) of the second day. IOP was measured 1 h and just before the intake of the supplement and 1 and 2 h after. All measurements in this group were taken 1 day before without any supplement (control) and the day of experiment.

Results

The DG group showed a significant decrease in IOP after supplement intake in all days of experiment, from 14.9 ± 3.4 mm Hg to 13.8 ± 2.9 mm Hg after 3 days of experiment (p value < 0.001). For AG, IOP did not change during the control day; however, a reduction of 1 mm Hg was found 2 and 3 h after supplement intake, from 15.7 ± 2.5 mm Hg to 14.7 ± 2.5 mm Hg and 15.1 ± 2.7 mm Hg, respectively, being statistically significant (p value < 0.001).

Conclusion

The supplement based on melatonin was able to reduce the IOP in normotensive subjects after 2 h of intake. Moreover, the daily intake showed a reduction in IOP during the 3 days of experiment.

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Funding

The authors do not have any financial interest on the materials and instruments used in this study, and this study was not funded by third parties.

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Authors and Affiliations

  1. Ocupharm Diagnostics Group Research, Faculty of Optic and Optometry, Department of Optometry and Vision, University Complutense of Madrid, C/Arcos del Jalon 118, 28032, Madrid, Spain

    Gonzalo Carracedo-Rodríguez, Julia Bodas-Romero, Juan Sanchez-Naves & Jesús Pintor

  2. Avizor S.A., Madrid, Spain

    Alejandro Martínez-Águila & Candela Rodriguez-Pomar

Authors
  1. Gonzalo Carracedo-Rodríguez
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  2. Alejandro Martínez-Águila
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  3. Candela Rodriguez-Pomar
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  4. Julia Bodas-Romero
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  5. Juan Sanchez-Naves
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  6. Jesús Pintor
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Corresponding author

Correspondence to Gonzalo Carracedo-Rodríguez.

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The authors declare that they have no conflict of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Carracedo-Rodríguez, G., Martínez-Águila, A., Rodriguez-Pomar, C. et al. Effect of nutritional supplement based on melatonin on the intraocular pressure in normotensive subjects. Int Ophthalmol 40, 419–422 (2020). https://doi.org/10.1007/s10792-019-01199-1

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  • DOI: https://doi.org/10.1007/s10792-019-01199-1

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