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The influence of mitomycin C concentration on the outcome of trabeculectomy in uveitic glaucoma

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Abstract

Purpose

To evaluate the influence of mitomycin C (MMC) concentration on the outcome of trabeculectomy in uveitic glaucoma.

Methods

Retrospective comparative study included 50 patients who underwent MMC-enhanced trabeculectomy for uncontrolled uveitic glaucoma. Patients were divided into two groups based on the concentration of MMC used during trabeculectomy (high [0.04%] or low [0.02%]). The main outcome measures were: the intraocular pressure (IOP), the number of antiglaucoma medications, the need for further glaucoma surgeries, and trabeculectomy success.

Results

There were no differences in the IOP nor antiglaucoma medications. The success rates were 76.0 and 68.0%, while the failure rates were 24.0 and 32.0% in the 0.02 and 0.04% MMC groups, respectively.

Conclusion

Trabeculectomy augmented with low (0.02%) MMC concentration seems to have comparable outcomes in uveitic glaucoma compared with high (0.04%) concentration.

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Acknowledgements

This work was supported by College of Medicine Research Center. Deanship of Scientific Research, King Saud University, Riyadh, Saudi Arabia.

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Authors and Affiliations

  1. Department of Ophthalmology, College of Medicine, King Saud University, P.O. Box 245, Riyadh, 11411, Saudi Arabia

    Faisal A. Almobarak

  2. Glaucoma Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia

    Faisal A. Almobarak, Ali H. Alharbi, Jose Morales & Ibrahim Aljadaan

  3. King Abdullah Medical City, Makkah, Saudi Arabia

    Ali H. Alharbi

Authors
  1. Faisal A. Almobarak
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  2. Ali H. Alharbi
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  3. Jose Morales
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  4. Ibrahim Aljadaan
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Correspondence to Faisal A. Almobarak.

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Almobarak, F.A., Alharbi, A.H., Morales, J. et al. The influence of mitomycin C concentration on the outcome of trabeculectomy in uveitic glaucoma. Int Ophthalmol 38, 2371–2379 (2018). https://doi.org/10.1007/s10792-017-0737-6

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  • DOI: https://doi.org/10.1007/s10792-017-0737-6

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