Abstract
We hereby report a case of endogenous endophthalmitis, presumably caused by a rare culprit—Aggregatibacter aphrophilus. A. aphrophilus is a member of the HACEK group, a group of fastidious Gram-negative bacteria with low pathogenicity and a rare cause of human infections. For ophthalmic infection, it has been reported to cause canaliculitis and exogenous endophthalmitis. A middle-aged gentleman with good past health presented with decreased vision (20/200) in his left eye. Other than fever, he was well on presentation, with no apparent focus of infection. Subsequently, he developed an episode of high fever reaching 39.2 °C, with CRP of 233 mg/L. CT abdomen showed presumed kidney abscess and a rare Gram-negative coccobacillus. A. aphrophilus [formerly Haemophilus aphrophilus (Nørskov-lauritsen and Kilian in Int J Syst Evol Microbiol 56:2135–2146, 2006)] was found in blood culture, Vitreous sample was analysed using 16S ribosomal DNA amplification but failed to identify the organism. After appropriate treatment, his vision improved drastically from 20/200 to 20/30. A. aphrophilus isolated from blood cultures during septicemia in a patient with kidney abscess may be associated with metastatic endophthalmitis, which may appear as a first sign. Our case demonstrates that with prompt diagnosis and appropriate treatment, visual prognosis of A. aphrophilus endophthalmitis can be promising.
References
Jackson TL, Eykyn SJ, Graham EM, Stanford MR (2003) Endogenous bacterial endophthalmitis: a 17-year prospective series and review of 267 reported cases. Surv Ophthalmol 48(4):403–423
Nørskov-lauritsen N, Kilian M (2006) Reclassification of Actinobacillus actinomycetemcomitans, Haemophilus aphrophilus, Haemophilus paraphrophilus and Haemophilus segnis as Aggregatibacter actinomycetemcomitans gen. nov., comb. nov., Aggregatibacter aphrophilus comb. nov. and Aggregatibacter segnis comb. nov., and emended description of Aggregatibacter aphrophilus to include V factor-dependent and V factorindependent isolates. Int J Syst Evol Microbiol 56:2135–2146
Huang ST, Lee HC, Lee NY, Liu KH, Ko WC (2005) Clinical characteristics of Haemophilus aphrophilus infections. J Microbiol Immunol Infect 38(4):271–276
Bieger RC, Brewer NS, Washington JA 2nd (1978) Haemophilus aphrophilus: a microbiologic and clinical review and case report of 42 cases. Medicine 57:345–355
Okhravi N, Adamson P, Carroll N, Dunlop A, Matheson MM, Towler HM et al (2000) PCR-based evidence of bacterial involvement in eyes with suspected intraocular infection. Invest Ophthalmol Vis Sci 41(11):3474–3479
Sugita S, Shimizu N, Watanabe K, Katayama M, Horie S, Ogawa M et al (2011) Diagnosis of bacterial endophthalmitis by broad-range quantitative PCR. Br J Ophthalmol 95(3):345–349
Alvarez O, Morales J, McCartney KL, May DR, Allison K (1991) Haemophilus aphrophilus endophthalmitis associated with a filtering bleb. Arch Ophthalmol 109:618–620
Macken PL, Boyd SR, Campbell I, Chang D, Rootman DS, Trope GE (1995) Haemophilus aphrophilus bleb infection after a mitomycin trabeculectomy. Aust N Z J Ophthalmol 23:323–325
Chee SP, Jap A (2001) Endogenous endophthalmitis. Curr Opin Ophthalmol 12(6):464–470
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Shum, J.W.H., Tsang, F.C.W., Fung, K.S.C. et al. Presumed Aggregatibacter aphrophilus endogenous endophthalmitis. Int Ophthalmol 35, 269–273 (2015). https://doi.org/10.1007/s10792-015-0044-z
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10792-015-0044-z