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Interleukin-35: a Potential Therapeutic Agent for Autoimmune Diseases

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Abstract

Autoimmune diseases contain a large number of pathologies characterized by various factors that contribute to a breakdown in self-tolerance. Cytokine-mediated immunity plays an essential role in the pathogenesis of varieties of autoimmune diseases. Recent studies reveal that interleukin-35 (IL-35), a newly identified cytokine of IL-12 family, is implicated in the pathogenesis of autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), systemic sclerosis (SSc), etc. In this review, we will discuss the biological features of IL-35 and summarize recent advances in the role of IL-35 in the development and pathogenesis of autoimmune diseases; the discoveries gained from these findings might translate into future therapies for these diseases.

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Acknowledgment

This work was supported by grants from the National Natural Science Foundation of China (81573222).

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  1. Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, PR China

    Shi-Yang Guan, Rui-Xue Leng, Muhammad Imran Khan, Humera Qureshi, Dong-Qing Ye & Hai-Feng Pan

  2. Anhui Provincial Laboratory of Population Health and Major Disease Screening and Diagnosis, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, China

    Shi-Yang Guan, Rui-Xue Leng, Muhammad Imran Khan, Humera Qureshi, Dong-Qing Ye & Hai-Feng Pan

  3. Department of Rheumatology and Immunology, Anhui Provincial Hospital, 17 Lujiang Road, Hefei, Anhui, China

    Xiang-Pei Li

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Guan, SY., Leng, RX., Khan, M.I. et al. Interleukin-35: a Potential Therapeutic Agent for Autoimmune Diseases. Inflammation 40, 303–310 (2017). https://doi.org/10.1007/s10753-016-0453-9

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