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Neuropeptide Downregulation in Sepsis

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Abstract

Neuropeptides are an extremely conserved arm of neurobiology. Despite their effects as neurohormones and neurotransmitters, a multitude of other effects have been described, putting in evidence their importance as regulators of immune responses, such as chemotaxis, oxidative burst, pro-inflammatory signaling, and many others. The effects of neuropeptides in the pathophysiology of sepsis, however, remain poorly investigated. A prospective cohort study to investigate the effects of neuropeptides in sepsis was carried out. Here, we describe that neuropeptides are downregulated during septic shock. We propose that it may be a protective mechanism of the host to avoid further inflammatory injury.

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Acknowledgments

The authors have no financial or ethical conflicts of interest. FPS is supported by FAPESP, São Paulo Research Foundation (grant no. 2009/17731-2).

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Correspondence to Fabiano Pinheiro da Silva.

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Pinheiro da Silva, F., César Machado, M.C., Sallet, P.C. et al. Neuropeptide Downregulation in Sepsis. Inflammation 37, 142–145 (2014). https://doi.org/10.1007/s10753-013-9722-z

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  • DOI: https://doi.org/10.1007/s10753-013-9722-z

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