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Plasma Levels of C-Telopeptide Pyridinoline Cross-Links of Type I Collagen and Osteocalcin in Chronic Periodontitis

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Abstract

This study was planned to investigate whether chronic periodontitis patients exhibit different plasma concentrations of C-telopeptide pyridinoline cross-links of type I collagen (ICTP) and osteocalcin (OC) compared to the clinically healthy controls. Before initiation of any periodontal intervention, plasma samples and full-mouth clinical periodontal recordings were obtained from 58 otherwise healthy patients with chronic periodontitis and also from 47 systemically and periodontally healthy control subjects. Plasma ICTP levels were determined by radioimmunoassay and OC levels by enzyme-linked immunosorbent assay. Data were tested statistically using t test and ANOVA. The healthy control group exhibited significantly lower values in all clinical periodontal measurements (P < 0.001). There were no significant differences between the study groups in plasma ICTP and OC levels (P > 0.05). Within the limits of this study, it may be suggested that plasma levels of ICTP and OC may not provide distinguishing data between chronic periodontitis patients and clinically healthy subjects.

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References

  1. Armitage, G.C. 1999. Development of a classification system for periodontal diseases and conditions. Annals of Periodontology 4: 1–6.

    Article  PubMed  CAS  Google Scholar 

  2. Lappin, D.F., B. Eapen, D. Robertson, J. Young, and P.J. Hodge. 2009. Markers of bone destruction and formation and periodontitis in type 1 diabetes mellitus. Journal of Clinical Periodontology 36: 634–641.

    Article  PubMed  CAS  Google Scholar 

  3. Yoshihara, A., T. Deguchi, N. Hanada, and H. Miyazaki. 2009. Relation of bone turnover markers to periodontal disease and jaw bone morphology in elderly Japanese subjects. Oral Diseases 15: 176–181.

    Article  PubMed  CAS  Google Scholar 

  4. Seibel, M.J. 2003. Biochemical markers of bone metabolism in the assessment of osteoporosis: useful or not? Journal of Endocrinological Investigation 26: 464–471.

    PubMed  CAS  Google Scholar 

  5. Narayanan, A.S., and R.C. Page. 1983. Connective tissues of the periodontium: a summary of current work. Collagen and Related Research 3: 33–64.

    PubMed  CAS  Google Scholar 

  6. Oringer, R.J., M.D. Palys, A. Iranmanesh, J.P. Fiorellini, A.D. Haffajee, S.S. Socransky, and W.V. Giannobile. 1998. C-telopeptide pyridinoline cross-links (ICTP) and periodontal pathogens associated with endosseous oral implants. Clinical Oral Implants Research 9: 365–373.

    Article  PubMed  CAS  Google Scholar 

  7. Oringer, R.J., K.F. Al-Shammari, W.A. Aldredge, V.J. Iacono, R.M. Eber, H.L. Wang, B. Berwald, R. Nejat, and W.V. Giannobile. 2002. Effect of locally delivered minocycline microspheres on markers of bone resorption. Journal of Periodontology 73: 835–842.

    Article  PubMed  CAS  Google Scholar 

  8. Giannobile, W.V. 1999. C-telopeptide pyridinoline cross-links. Sensitive indicators of periodontal tissue destruction. Annals of the New York Academy of Sciences 878: 404–412.

    Article  PubMed  CAS  Google Scholar 

  9. Lian, J.B., and C.M. Gundberg. 1988. Osteocalcin: biochemical considerations and clinical applications. Clinical Orthopaedics and Related Research 226: 267–291.

    PubMed  CAS  Google Scholar 

  10. Christerson, R.H. 1997. Biochemical markers of bone metabolism: an overview. Clinical Biochemistry 30: 573–593.

    Article  Google Scholar 

  11. Shi, F., S. Yu, and L. Xu. 1996. Analysis of serum osteocalcin of patients with periodontitis. Zhonghua Kou Qiang Yi Xue Za Zhi 31: 300–302. Article in Chinese.

    PubMed  CAS  Google Scholar 

  12. Buduneli, E., N. Buduneli, S. Vardar-Şengül, L. Kardeşler, G. Atilla, D. Lappin, and D.F. Kinane. 2005. Systemic low-dose doxycycline and alendronate administration and serum interleukin-1beta, osteocalcin, and C-reactive protein levels in rats. Journal of Periodontology 76: 1927–1933.

    Article  PubMed  CAS  Google Scholar 

  13. Tümer, C., Y. Aksoy, G.N. Güncü, R.M. Nohutçu, K. Kılınç, and T.F. Tözüm. 2008. Possible impact of inflammatory status on C-telopeptide pyridinoline cross-links of type I collagen and osteocalcin levels around oral implants with peri-implantitis: a controlled clinical trial. Journal of Oral Rehabilitation 35: 934–939.

    Article  PubMed  Google Scholar 

  14. Oringer, R.J., K.F. Al-Shammari, and D.P. Sarment. 2003. Matrix molecules and growth factors as indicators of periodontal disease activity. Periodontology 2000 31: 125–134.

    Google Scholar 

  15. Gürlek, Ö., D.F. Lappin, and N. Buduneli. 2009. Effects of smoking on salivary C-telopeptide pyridinoline cross-links of type I collagen and osteocalcin levels. Archives of Oral Biology 54: 1099–1104.

    Article  PubMed  Google Scholar 

  16. Bullon, P., B. Goberna, J.M. Guerro, J.J. Segura, R. Parez-Cano, and A. Martinez-Sahuguillo. 2005. Serum, saliva and gingival crevicular fluid osteocalcin: their relation to periodontal status and bone mineral density in postmenopausal women. Journal of Periodontology 76: 513–519.

    Article  PubMed  CAS  Google Scholar 

  17. Kunimatsu, K., S. Mataki, H. Tanaki, N. Mine, M. Kiyoki, K. Hosoda, Y. Kato, and I. Kato. 1993. A cross-sectional study on osteocalcin levels in gingival crevicular fluid from periodontal patients. Journal of Periodontology 64: 865–869.

    PubMed  CAS  Google Scholar 

  18. Nakashima, K., N. Roehrich, and G. Cimasoni. 1994. Osteocalcin, prostaglandin E2 and alkaline phosphatase in gingival crevicular fluid: their relations to periodontal status. Journal of Clinical Periodontology 21: 327–333.

    Article  PubMed  CAS  Google Scholar 

  19. Lee, A.J., T.F. Walsh, S.J. Hodges, and A. Rawlinson. 1999. Gingival crevicular fluid osteocalcin in adult periodontitis. Journal of Clinical Periodontology 26: 252–256.

    Article  PubMed  CAS  Google Scholar 

  20. Murata, M., J. Tatsumi, Y. Kato, S. Suda, Y. Nunokawa, Y. Kobayashi, H. Takeda, H. Araki, K. Shin, K. Okuda, T. Miyata, and H. Yoshie. 2002. Osteocalcin, deoxypyridinoline and interleukin-1beta in peri-implant crevicular fluid of patients with peri-implantitis. Clinical Oral Implants Research 13: 637–643.

    Article  PubMed  Google Scholar 

  21. Koyama, K., K. Ohara, H. Yokota, T. Kurome, M. Katayama, and F. Hino. 1991. A one step sandwich enzyme immunoassay for γ-carboxylated osteocalcin using monoclonal antibodies. Journal of Immunological Methods 139: 17–23.

    Article  PubMed  CAS  Google Scholar 

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Source of Funding

This study has been funded solely by the institutions of the authors.

Conflict of Interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Periodontology, School of Dentistry, Ege University, Bornova, 35100, İzmir, Turkey

    Özgün Özçaka, Nurgün Bıçakçı & Nurcan Buduneli

  2. Department of Bioengineering, Faculty of Engineering, Ege University, Bornova, 35100, İzmir, Turkey

    Ayşe Nalbantsoy

  3. Department of Biostatistics and Medical Informatics, School of Medicine, Ege University, Bornova, 35100, İzmir, Turkey

    Timur Köse

Authors
  1. Özgün Özçaka
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  2. Ayşe Nalbantsoy
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  3. Nurgün Bıçakçı
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  4. Timur Köse
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  5. Nurcan Buduneli
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Correspondence to Nurcan Buduneli.

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Özçaka, Ö., Nalbantsoy, A., Bıçakçı, N. et al. Plasma Levels of C-Telopeptide Pyridinoline Cross-Links of Type I Collagen and Osteocalcin in Chronic Periodontitis. Inflammation 34, 203–208 (2011). https://doi.org/10.1007/s10753-010-9225-0

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  • DOI: https://doi.org/10.1007/s10753-010-9225-0

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