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Imbalance Between Macrophage Migration Inhibitory Factor and Cortisol Induces Multiple Organ Dysfunction in Patients with Blunt Trauma

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Abstract

Migration inhibitory factor (MIF) is associated with multiple organ dysfunction syndrome (MODS) in patients with systemic inflammatory response syndrome (SIRS). Our purposes were to determine the serum MIF, cortisol, and tumor narcosis factor-α (TNF-α) and to investigate the influences of the balance between the levels of MIF and cortisol in patients with blunt trauma. The cortisol levels were identical between the patients with and without MODS. However, the MIF and TNF-α levels in the patients with MODS were statistically higher than those of the patients without MODS. The cortisol/MIF ratios in the patients with MODS were statistically higher than those of the patients without MODS. The results show that MIF and TNF-α play an important role together in posttraumatic inflammatory response. An excessive serum MIF elevation overrides the anti-inflammatory effects of cortisol and leads to persistent SIRS followed by MODS in blunt trauma patients.

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Authors and Affiliations

  1. Emergency and Critical Care Center, Hokkaido University Hospital, N14W5 Kita-ku, Sapporo, 060-8648, Japan

    Mineji Hayakawa, Kenichi Katabami, Takeshi Wada, Yousuke Minami, Masahiro Sugano, Hidekazu Shimojima, Nobuhiko Kubota, Shinji Uegaki, Atsushi Sawamura & Satoshi Gando

Authors
  1. Mineji Hayakawa
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  2. Kenichi Katabami
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  3. Takeshi Wada
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  4. Yousuke Minami
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  5. Masahiro Sugano
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  6. Hidekazu Shimojima
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  7. Nobuhiko Kubota
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  8. Shinji Uegaki
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  9. Atsushi Sawamura
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  10. Satoshi Gando
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Correspondence to Mineji Hayakawa.

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Hayakawa, M., Katabami, K., Wada, T. et al. Imbalance Between Macrophage Migration Inhibitory Factor and Cortisol Induces Multiple Organ Dysfunction in Patients with Blunt Trauma. Inflammation 34, 193–197 (2011). https://doi.org/10.1007/s10753-010-9223-2

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  • DOI: https://doi.org/10.1007/s10753-010-9223-2

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