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Efficacy and Mechanism of Salvia Miltiorrhizae Injection in the Treatment of Rats with Severe Acute Pancreatitis

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To study the efficacy and mechanism of Salvia miltiorrhizae injection in the treatment of severe acute pancreatitis. SAP rat models were prepared and randomly divided into model control group and treated group. The sham-operated group was also set. At 3, 6 and 12 h after operation, the mortality rate, ascitic volumes, pathological changes in the pancreas, contents of amylase and endotoxin in plasma as well as IL-6, IL-18, ET-1 and NO in serum, the staining intensity of Bax and NF-κB p56 proteins, and the changes in apoptosis index of pancreatic cells in rats in each group were observed. The pathological severity scores (at 3, 6 and 12 h after operation), contents of plasma endotoxin (at 6 and 12 h after operation) and serum IL-6 (at 6 and 12 h after operation) were significantly lower than those in model control group (P < 0.05, P < 0.01 and P < 0.01, respectively); the staining intensity and the product of the staining intensity and positive staining rate of Bax protein in the pancreas were significanly higher than those in model control group (P < 0.01). Salvia miltiorrhizae is able to reduce the contents of plasma endotoxin and serum IL-6, promote the expression of Bax protein in pancreas, improve the pathological changes in the pancreas, and decrease the mortality rate of rats, thereby showing therapeutic effect on rats with SAP.

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Authors and Affiliations

  1. Department of Orthopaedics or Department of Radiology, First Clinical Medical College of Shanxi Medical University, Taiyuan, Shanxi Province, 030001, China

    Zhang Ruiping

  2. Department of General Surgery, Hangzhou First People’s Hospital, Hangzhou, 310006, Zhejiang Province, China

    Zhang Xiping, Ye Jing, Fang Xin, Jin Lu, He Jiao & Yuan Wenqin

  3. Zhejiang University of Traditional Chinese Medical, Hangzhou, 310053, Zhejiang Province, China

    Zhang Jie, Wu Junsheng & Ye Qian

  4. Department of Pathology, Hangzhou First People’s Hospital, Hangzhou, 310006, Zhejiang Province, China

    Xu Rujun

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Correspondence to Zhang Ruiping.

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Supported by technological foundation project of Traditional Chinese Medicine Science of Zhejiang province (no. 2003C130; no. 2004C142), foundation project for medical science and technology of Zhejiang province (no. 2003B134), grave foundation project for technological and development of Hangzhou (no. 2003123B19), intensive foundation project for technology of Hangzhou (no. 2004Z006), foundation project for medical science and technology of Hangzhou (no. 2003A004) and foundation project for technology of Hangzhou (no. 2005224)

We claimed that this paper was original and would not have any financial interest in a company or its competitor, and that all authors meet standard for authorship. We abided the ethics in this animal experiment study. The ethics committee approval of our hospital was secured for the animal study reported, and all rats have not been abused and executive mercy killing when the observing time in this study was over.

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Ruiping, Z., Xiping, Z., Jie, Z. et al. Efficacy and Mechanism of Salvia Miltiorrhizae Injection in the Treatment of Rats with Severe Acute Pancreatitis. Inflammation 32, 109–119 (2009). https://doi.org/10.1007/s10753-009-9109-3

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