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Sustained Monocyte Activation in Clinical Remission of Systemic Vasculitis

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Abstract

Monocytes have been shown to be activated in ANCA-positive systemic vasculitis, but their state of activation in clinical remission is unknown.Fifteen patients with a new diagnosis of systemic vasculitis were included in the study. Blood samples were analysed at diagnosis and at clinical remission after three to six months. The expression of adhesion molecules (CD62L and CD11b) on monocytes and the serum concentration of the endothelium activation factor VEGF and the chemokine MIP-1α were determined.We demonstrate an increased expression of CD11b on monocytes from patients with acute vasculitis that is sustained in clinical remission. The increased state of activation in clinical remission was accompanied by a decrease in VEGF and MIP-1α levels. This generates the intriguing question whether a treatment targeted to normalize monocyte activation in clinical remission would have an impact on relapse rate and outcome in this group of patients with high risk of systemic and renal complications.

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Acknowledgements

We would like to thank Titti Nieminen for excellent technical assistance, and Agneta Pagels, for providing the blood samples. This investigation was supported by grants from the Karolinska Institutet.

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Authors and Affiliations

  1. Division of Clinical Immunology and Transfusion Medicine, Huddinge Karolinska University Hospital, SE-141 86, Stockholm, Sweden

    Agneta Wikman & Joachim Lundahl

  2. Division of Nephrology, Danderyd Hospital and Karolinska Institute, Stockholm, Sweden

    Stefan H. Jacobson

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  1. Agneta Wikman
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  2. Joachim Lundahl
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  3. Stefan H. Jacobson
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Correspondence to Agneta Wikman.

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Wikman, A., Lundahl, J. & Jacobson, S.H. Sustained Monocyte Activation in Clinical Remission of Systemic Vasculitis. Inflammation 31, 384–390 (2008). https://doi.org/10.1007/s10753-008-9089-8

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  • DOI: https://doi.org/10.1007/s10753-008-9089-8

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