Abstract
In this paper we take the view that computational models of biological systems should satisfy two conditions – they should be able to predict function at a systems biology level, and robust techniques of validation against biological models must be available. A modelling paradigm for developing a predictive computational model of cellular interaction is described, and methods of providing robust validation against biological models are explored, followed by a consideration of software issues.
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Smallwood, R.H., Holcombe, W.M.L. & Walker, D.C. Development and validation of computational models of cellular interaction. Histochem J 35, 659–665 (2004). https://doi.org/10.1007/s10735-004-2660-1
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DOI: https://doi.org/10.1007/s10735-004-2660-1