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Concerns about inherited risk of breast cancer prior to diagnosis in Japanese patients with breast complaints

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Abstract

The purpose of this study was to reveal characteristics that underlie patients’ expressions of concern about their genetic risk of breast cancer at an initial outpatient clinic visit prior to a definitive diagnosis of cancer. A total of 233 women, at their initial outpatient clinic visits, participated in semi-structured and open-ended interviews that surveyed their anxieties, worries, thoughts, and feelings. Each patient completed a self-administered survey comprising questions about her family history of breast cancer and responded to a questionnaire that assessed psychological distress. Patients were divided into those who expressed concerns about inherited risk of breast cancer during the interview (expression group, n = 39) and those who did not (non-expression group, n = 194). Although patients in the expression group tended to have higher rates of breast cancer in their families, patients without a family history of breast cancer also expressed concerns. We used qualitative content analysis to identify the emotions and thoughts of patients expressing these concerns. Patients with a family history of breast cancer experienced anxiety/worry, risk-reducing behavior, acceptance, objective fact, and denial, whereas patients without a family history of breast cancer experienced anxiety/worry, risk-reducing behavior, surprise/shock, acceptance, objective fact, denial, optimistic thought, regret, and realistic thought. Some patients in the breast clinic had concerns about their inherited risk of cancer, despite lacking a family history of breast cancer. Health care professionals should inquire about family histories and provide appropriate support and counseling to patients as needed, regardless of the patient’s genetic risk for the disease.

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Acknowledgments

The authors wish to acknowledge the contributions of all study participants. This work was supported by a Grant-in-Aid for Research Activity Start-up (No. 22830078) and a Grant-in-Aid for Scientific Research (C) (No. 22530757) from the Ministry of Education, Culture, Sports, Science and Technology of Japan.

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Authors and Affiliations

  1. Department of Medical Psychology, Pharmaceutical Education Research Center, Kitasato University School of Pharmacy, Minato, Tokyo, Japan

    Noriko Ando

  2. Department of Medical Psychology, Graduate School of Medical Sciences, Kitasato University, Sagamihara, Kanagawa, Japan

    Yumi Iwamitsu & Shigemi Okazaki

  3. Department of Surgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan

    Masaru Kuranami & Masahiko Watanabe

  4. Department of Psychiatry, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan

    Kenji Yamamoto & Hitoshi Miyaoka

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  1. Noriko Ando
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  2. Yumi Iwamitsu
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  3. Masaru Kuranami
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  4. Shigemi Okazaki
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  5. Kenji Yamamoto
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  6. Masahiko Watanabe
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  7. Hitoshi Miyaoka
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Correspondence to Noriko Ando.

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Ando, N., Iwamitsu, Y., Kuranami, M. et al. Concerns about inherited risk of breast cancer prior to diagnosis in Japanese patients with breast complaints. Familial Cancer 10, 681–689 (2011). https://doi.org/10.1007/s10689-011-9464-8

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  • DOI: https://doi.org/10.1007/s10689-011-9464-8

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