Abstract
Heavy metals (HMs) are extensively found in occupationally exposed miners and industrial workers, which may cause serious health-related problems to the large workforce. In order to evaluate the impact of these toxic pollutants, we have investigated the effect of cadmium (Cd), chromium (Cr), copper (Cu), and lead (Pb) concentration on exposed workers of mining, and woolen textile mill and compared the findings with unexposed individuals. From each category like exposed workers (mining, and woolen mill textile site) and unexposed individuals, 50 blood samples were taken. The occurrence of HMs in a sample was investigated through atomic absorption spectrometry while the oxidative stress marker malondialdehyde (MDA) and antioxidant enzyme statuses such as superoxide dismutase (SOD) and catalase (CAT) were analyzed in exposed and control samples. The results showed significant (p < 0.05) variation in Cd, Cr, Cu, and Pb levels in exposed and control samples. The concentration of Cd in the blood of WMWs, KMWs, and control group was 5.75, 3.89, and 0.42 μg/dL, respectively. On the other hand, the concentration of Pb in the blood of WMWs, MWs, and control was 32.34, 24.39, and 0.39 µg/dL while the concentrations of Cr and Cu in the blood of WMWs, MWs, and control group were 11.61 and 104.14 μg/dL, 4.21 and 113.21 μg/dL, 0.32 and 65.53 μg/dL, respectively. An increase in MDA was recorded in the exposed workers' group as compared to control subjects, whereas SOD and CAT activities decreased. Meanwhile, MDA was significantly and positively (p < 0.01) correlated with HMs, while negative significant correlations were found among HMs with SOD and CAT.
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The data sets used and/or analyzed during the current study are available from the corresponding author upon reasonable request.
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KK was involved in formal analysis and writing—original draft. MTR helped in conceptualization, data curation, and writing—original draft preparation. A-U-RB contributed to data curation, writing (original draft preparation, reviewing, and editing). IN was involved in writing—reviewing and editing. MI helped in review and revision of manuscript suggested by reviewers. FF contributed to review and revision of manuscript suggested by reviewers. MY was involved in writing—reviewing and editing. MDK helped in writing—reviewing and editing. RA contributed to writing—reviewing and editing. MA helped in review and revision of the manuscript. AA helped in in review and revision of the manuscript. SA helped in review and revision of the manuscript. AI helped in review and revision of the manuscript. All authors read and approved the final manuscript.
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Khan, K., Rafiq, M.T., Bacha, AUR. et al. Assessment of heavy metals and associated oxidative stress in occupationally exposed workers from Bannu and Karak Districts in Pakistan. Environ Geochem Health 45, 5915–5925 (2023). https://doi.org/10.1007/s10653-023-01603-x
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DOI: https://doi.org/10.1007/s10653-023-01603-x