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Enhanced Visibility in Evaluating Gastric Cancer and Helicobacter pylori-Associated Gastritis Using Linked Color Imaging with a Light-Emitting Diode Light Source

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Digestive Diseases and Sciences Aims and scope Submit manuscript

An Editorial to this article was published on 31 August 2021

Abstract

Background

In Japan, laser light source (Laser) endoscopy is widely available, and the characteristics of light-emitting diode light source (LED) endoscopy have not been clarified.

Aims

We assessed the visibility of early gastric cancers (EGCs) and Helicobacter pylori (H. pylori)-associated gastritis for LED endoscopy compared with laser endoscopy using white-light imaging (WLI) and linked color imaging (LCI).

Methods

We assessed 99 lesions between February 2019 and March 2020. The visibility was scored from four (excellent visibility) to one (poor visibility) by evaluating videos including EGCs and gastric mucosa captured using WLI and LCI with LED endoscopy (LED-WLI and LED-LCI, respectively) and laser endoscopy (Laser-WLI and Laser-LCI, respectively). The primary end point was the non-inferiority of the visibility of EGCs and H. pylori-associated gastritis between LED-/Laser-WLI and LED-/Laser-LCI.

Results

The visibility scores of EGCs for LED-/Laser-WLI and LED-/Laser-LCI were 3.14/2.97 and 3.39/3.35, respectively. The visibility scores of H. pylori-associated gastritis [intestinal metaplasia (IM), diffuse redness (DR), regular arrangement of collecting venules (RAC) and map-like redness (MR)] for LED-/Laser-WLI and LED-/Laser-LCI were 3.05/2.85 and 3.60/3.50 (IM), 2.76/2.50 and 2.96/2.86 (DR), 2.69/2.44 and 2.77/2.62 (RAC) and 2.97/2.75 and 3.39/3.27 (MR). Non-inferiority was demonstrated for visualizing EGCs and H. pylori-associated gastritis.

Conclusions

LED-WLI and LED-LCI can be used to visualize EGCs and H. pylori-associated gastritis with non-inferiority to Laser-WLI and Laser-LCI. Furthermore, even with LED, LCI was more effective than WLI for evaluating EGCs and H. pylori-associated gastritis. Therefore, LED endoscopy can be used to detect EGCs and evaluate H. pylori-associated gastritis accurately.

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References

  1. Uemura N, Okamoto S, Yamamoto S et al. Helicobacter pylori infection and the development of gastric cancer. N Engl J Med. 2001;345:784–789.

    Article  CAS  Google Scholar 

  2. Masuyama H, Yoshitake N, Sasai T et al. Relationship between the degree of endoscopic atrophy of the gastric mucosa and carcinogenic risk. Digestion. 2015;91:30–36.

    Article  Google Scholar 

  3. Spence AD, Cardwell CR, McMenamin Ú et al. Adenocarcinoma risk in gastric atrophy and intestinal metaplasia: a systematic review. BMC Gastroenterol. 2017;17:157.

    Article  Google Scholar 

  4. Sugano K, Tack J, Kuipers EJ et al. Kyoto global consensus report on Helicobacter pylori gastritis. Gut. 2015;64:1353–1367.

    Article  Google Scholar 

  5. Sugimoto M, Ban H, Ichikawa H et al. Efficacy of the Kyoto Classification of Gastritis in Identifying Patients at High Risk for Gastric Cancer. Intern Med. 2017;56:579–586.

    Article  Google Scholar 

  6. Yoshii S, Mabe K, Watano K et al. Validity of endoscopic features for the diagnosis of Helicobacter pylori infection status based on the Kyoto classification of gastritis. Dig Endosc. 2020;32:74–83.

    Article  Google Scholar 

  7. Dohi O, Majima A, Naito Y et al. Can image-enhanced endoscopy improve the diagnosis of Kyoto classification of gastritis in the clinical setting? Dig Endosc. 2020;32:191–203.

    Article  Google Scholar 

  8. Ono S, Dohi O, Yagi N et al. Accuracies of Endoscopic Diagnosis of Helicobacter pylori-Gastritis: Multicenter Prospective Study Using White Light Imaging and Linked Color Imaging. Digestion. 2020;101:624–630.

    Article  Google Scholar 

  9. Takeda T, Asaoka D, Nojiri S et al. Linked Color Imaging and the Kyoto Classification of Gastritis: Evaluation of Visibility and Inter-Rater Reliability. Digestion. 2020;101:598–607.

    Article  Google Scholar 

  10. Kaneko K, Oono Y, Yano T et al. Effect of novel bright image enhanced endoscopy using blue laser imaging (BLI). Endosc Int Open. 2014;2:E212–E219.

    Article  Google Scholar 

  11. Fukuda H, Miura Y, Hayashi Y et al. Linked color imaging technology facilitates early detection of flat gastric cancers. Clin J Gastroenterol. 2015;8:385–389.

    Article  Google Scholar 

  12. Yoshifuku Y, Sanomura Y, Oka S et al. Evaluation of the visibility of early gastric cancer using linked color imaging and blue laser imaging. BMC Gastroenterol. 2017;17:150.

    Article  Google Scholar 

  13. Dohi O, Yagi N, Naito Y et al. Blue laser imaging-bright improves the real-time detection rate of early gastric cancer: a randomized controlled study. Gastrointest Endosc. 2010;89:47–57.

    Article  Google Scholar 

  14. Gao J, Zhang X, Meng Q et al. Linked color imaging can improve detection rate of early gastric cancer in a high-risk population: a multi-center randomized controlled clinical trial. Dig Dis Sci. 2021;66:1212–1219.

    Article  Google Scholar 

  15. Ono S, Kawada K, Dohi O et al. Linked Color Imaging Focused on Neoplasm Detection in the Upper Gastrointestinal Tract: A Randomized Trial. Ann Intern Med. 2021;174:18–24. https://doi.org/10.7326/M19-2561 (Epub 2020 Oct 20).

    Article  PubMed  Google Scholar 

  16. Majima A, Dohi O, Takayama S et al. Linked color imaging identifies important risk factors associated with gastric cancer after successful eradication of Helicobacter pylori. Gastrointest Endosc. 2019;90:763–769.

    Article  Google Scholar 

  17. Yoshida N, Dohi O, Inoue K et al. Blue Laser Imaging, Blue Light Imaging, and Linked Color Imaging for the Detection and Characterization of Colorectal Tumors. Gut Liver. 2019;13:140–148.

    Article  Google Scholar 

  18. Japanese gastric cancer treatment guidelines 2014 (ver. 4). Gastric Cancer. 2017;20:1–19.

  19. Yoshida N, Hisabe T, Hirose R et al. Improvement in the visibility of colorectal polyps by using blue laser imaging (with video). Gastrointest Endosc. 2015;82:542–549.

    Article  Google Scholar 

  20. Suzuki T, Hara T, Kitagawa Y et al. Linked-color imaging improves endoscopic visibility of colorectal nongranular flat lesions. Gastrointest Endosc. 2017;86:692–697.

    Article  Google Scholar 

  21. Kitagawa Y, Suzuki T, Hara T et al. Linked color imaging improves the endoscopic visibility of gastric mucosal cancers. Endosc Int Open. 2019;7:E164–E170.

    Article  Google Scholar 

  22. Kitagawa Y, Suzuki T, Nankinzan R et al. Comparison of endoscopic visibility and miss rate for early gastric cancers after Helicobacter pylori eradication with white-light imaging versus linked color imaging. Dig Endosc. 2020;32:769–777. https://doi.org/10.1111/den.13585 (Epub 2019 Dec 26).

    Article  PubMed  Google Scholar 

  23. Gwet KL. Computing inter-rater reliability and its variance in the presence of high agreement. Br J Math Stat Psychol. 2008;61:29–48.

    Article  Google Scholar 

  24. Yoshida N, Naito Y, Yasuda R et al. Linked color imaging improves the visibility of various featured colorectal polyps in an endoscopist’s visibility and color difference value. Int J Colorectal Dis. 2017;32:1253–1260.

    Article  Google Scholar 

  25. Takayama S, Dohi O, Naito Y et al. Diagnostic ability of magnifying blue light imaging with a light emitting diode light source for early gastric cancer: a prospective comparative study. Digestion. 2021;102:580–589.

    Article  CAS  Google Scholar 

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Acknowledgments

We thank all members of the Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, for helping us perform this study.

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Authors and Affiliations

  1. Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kawaramachi Hirokoji Kamigyo-ku, Kyoto, 602-8566, Japan

    Tsugitaka Ishida, Osamu Dohi, Naohisa Yoshida, Takeshi Yasuda, Takuma Yoshida, Yuka Azuma, Hiroaki Kitae, Shinya Matsumura, Toshifumi Doi, Ryohei Hirose, Ken Inoue, Kazuhiro Kamada, Kazuhiko Uchiyama, Takeshi Ishikawa, Tomohisa Takagi, Hideyuki Konishi, Yuji Naito & Yoshito Itoh

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  1. Tsugitaka Ishida
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  2. Osamu Dohi
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Corresponding author

Correspondence to Osamu Dohi.

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Conflict of interest

Osamu Dohi received a research grant from Fujifilm Co., Ltd. (J192001048 and J192001259). Naohisa Yoshida received a research grant from Fujifilm Co., Ltd. (J162001222). The other authors have no conflicts of interest to declare. Fujifilm Co., Ltd., had no role in the design, conduct, data collection, data interpretation or reporting of this study.

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Ishida, T., Dohi, O., Yoshida, N. et al. Enhanced Visibility in Evaluating Gastric Cancer and Helicobacter pylori-Associated Gastritis Using Linked Color Imaging with a Light-Emitting Diode Light Source. Dig Dis Sci 67, 2367–2374 (2022). https://doi.org/10.1007/s10620-021-07234-5

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