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Two-Channel Gastric Electrical Stimulation Accelerates Delayed Gastric Emptying Induced by Vasopressin

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Abstract

The aim of this study was to investigate the effects of two-channel gastric electrical stimulation (GES) on delayed gastric emptying, gastric dysrhythmias, and motion sickness-like symptoms induced by vasopressin. Seven dogs implanted with four pairs of gastric electrodes and a duodenal cannula were studied in four randomized sessions (saline, vasopressin, single-channel GES, and two-channel GES). The experiment in each session was conducted sequentially as follows: 30-min baseline, ingestion of a liquid meal, 30-min iv infusion of vasopressin or saline, and two 30-min postprandial recordings. In the GES sessions, GES was applied via the first pair of electrodes for single-channel GES or the first and third pairs of electrodes for two-channel GES. Gastric emptying was collected every 15 min via the cannula for a period of 90 min. Results were as follows. (1) Vasopressin induced gastric dysrhythmias, motion sickness-like symptoms, and delayed gastric emptying (P < 0.01, ANOVA). (2) GES normalized gastric dysrhythmias (P < 0.01) but showed no effects on vasopressin-induced emetic response. (3) Two-channel GES improved delayed gastric emptying induced by vasopressin. In comparison with the vasopressin session, two-channel GES, but not single-channel GES, significantly increased gastric emptying at 30 min (43.9 ± 12.6 vs. 27.5 ± 7.7%; P < 0.03), 60 min (75.3 ± 15.1 vs. 54.0 ± 17.8%; P < 0.05), and 90 min (91.6 ± 9.8 vs. 80.3 ± 9.0%; P < 0.05). GES with long pulses is able to normalize gastric dysrhythmias. Two-channel GES improves delayed gastric emptying induced by vasopressin.

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Authors and Affiliations

  1. Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China

    Gengqing Song MD, Xiaohua Hou MD, PhD, Bin Yang MD, Jinsong Liu MD & Wei Qian

  2. Division of Gastroenterology, University of Texas Medical Branch, Galveston, Texas, USA

    Jiande D. Z. Chen PhD

  3. GI Research, Route 0632, Room 221, 1108 The Strand, Galveston, Texas, 77059, USA

    Jiande D. Z. Chen PhD

Authors
  1. Gengqing Song MD
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  2. Xiaohua Hou MD, PhD
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  3. Bin Yang MD
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  4. Jinsong Liu MD
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  5. Wei Qian
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  6. Jiande D. Z. Chen PhD
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Correspondence to Jiande D. Z. Chen PhD.

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Song, G., Hou, X., Yang, B. et al. Two-Channel Gastric Electrical Stimulation Accelerates Delayed Gastric Emptying Induced by Vasopressin. Dig Dis Sci 50, 662–668 (2005). https://doi.org/10.1007/s10620-005-2553-5

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  • DOI: https://doi.org/10.1007/s10620-005-2553-5

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