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Current and Promising Pharmacotherapies for Substance Use Disorders among Justice-Involved Populations

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Abstract

Growing recognition of the biological underpinnings of substance use disorders (SUDs) has led to increased acceptance of pharmacotherapy-based treatments for general populations and, more recently, for individuals under criminal justice supervision, including those in correctional settings. This paper focuses on pharmacotherapies that have been approved by the United States Food and Drug Administration (FDA) for treatment of alcohol use disorder and opioid use disorder. For alcohol use disorder, these medications are disulfiram, naltrexone, and acamprosate; for opioid use disorder, these are methadone, buprenorphine, and naltrexone. Promising pharmacotherapies for stimulant use disorder are also briefly summarized. The paper concludes with three “lessons learned,” specifically: (1) treatment and policy should reflect the fact that substance misuse and addiction is a medical disorder, (2) interventions for SUDs should be integrated into primary care, and (3) reductions in substance use among pharmacotherapy-treated patients do not necessarily lead to concomitant reductions in crime (nor should this be the primary rationale for providing such treatment).

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Notes

  1. I prefer the term “SUD medication” over the more commonly used “medication-assisted treatment (MAT)” because the latter suggests that the medication provides only a supplemental role to psychosocial treatments, which has little empirical support.

  2. This may be more aptly attributed to the strong association between alcohol and predatory crime, rather than a weak drug-crime relationship.

  3. While reductions in levels of drug use can be justified on a cost basis, treatment of SUD should be given parity with the treatment of other medical disorders, without regard to the potential impact on recidivism risk.

References

  • Altice, F. L., Kamarulzaman, A., Soriano, V. V., Schechter, M., & Friedland, G. H. (2010). Treatment of medical, psychiatric, and substance-use comorbidities in people infected with HIV who use drugs. The Lancet, 376(9738), 367–387.

    Article  Google Scholar 

  • Anton, R. F., O’Malley, S. S., Ciraulo, D. A., Cisler, R. A., Couper, D., Donovan, D. M., Gastfriend, D. R., Hosking, J. D., Johnson, B. A., LoCastro, J. S., & Longabaugh, R. (2006). Combined pharmacotherapies and behavioral interventions for alcohol dependence: The COMBINE study: A randomized controlled trial. JAMA, 295(17), 2003–2017.

    Article  Google Scholar 

  • Binswanger, I. A., Stern, M. F., Deyo, R. A., Heagerty, P. J., Cheadle, A., Elmore, J. G., & Koepsell, T. D. (2007). Release from prison—a high risk of death for former inmates. The New England Journal of Medicine, 356(2), 157–165

  • Brahen, L. S., Henderson, R. K., Capone, T., & Kordal, N. (1984). Naltrexone treatment in a jail work-release program. Journal of Clinical Psychiatry, 45, 49–52.

    Google Scholar 

  • Degenhardt, L., Charlson, F., Mathers, B., Hall, W. D., Flaxman, A. D., Johns, N., & Vos, T. (2014). The global epidemiology and burden of opioid dependence: results from the global burden of disease 2010 study. Addiction, 109(8), 1320–1333.

  • Dolan, K. A., Shearer, J., MacDonald, M., Mattick, R. P., Hall, W., & Wodak, A. D. (2003). A randomised controlled trial of methadone maintenance treatment versus wait list control in an Australian prison system. Drug and Alcohol Dependence, 72(1), 59–65.

    Article  Google Scholar 

  • Douaihy, A. B., Kelly, T. M., & Sullivan, C. (2013). Medications for substance use disorders. Social Work in Public Health, 28(3–4), 264–278.

    Article  Google Scholar 

  • Eastwood, N., Fox, E., & Rosmarin, A. (2016). A quiet revolution: Drug decriminalisation across the globe. London: Release.

    Google Scholar 

  • Farabee, D., Joshi, V., & Anglin, M. D. (2001). Addiction careers and criminal specialization. Crime & Delinquency, 47(2), 196–220.

    Article  Google Scholar 

  • Farabee, D., Hillhouse, M., Condon, T., McCrady, B., McCollister, K., & Ling, W. (2016). Injectable pharmacotherapy for opioid use disorders (IPOD). Contemporary Clinical Trials, 49(8), 70–77.

    Article  Google Scholar 

  • Farre, M., Mas, A., Torrens, M., Moreno, V., & Cami, J. (2002). Retention rate and illicit opioid use during methadone maintenance interventions. Drug and Alcohol Dependence, 65(3), 283–290.

    Article  Google Scholar 

  • Farrell, M., & Marsden, J. (2008). Acute risk of drug‐related death among newly released prisoners in England and Wales. Addiction, 103(2), 251–255.

  • Fassino, S., Daga, G. A., Delsedime, N., Rogna, L., & Boggio, S. (2004). Quality of life and personality disorders in heroin abusers. Drug and Alcohol Dependence, 76(1), 73–80.

    Article  Google Scholar 

  • Fuller, R. K., & Gordis, E. (2004). Does disulfirum have a role in alcoholism treatment today? Addiction, 99(1), 21–24.

    Article  Google Scholar 

  • Fuller, R. K., Branchey, L., Brightwell, D. R., Derman, R. M., Emrick, C. D., Iber, F. L., James, K. E., Lacoursiere, R. B., Lee, K. K., Lowenstam, I., & Maany, I. (1986). Disulfiram treatment of alcoholism: A veterans administration cooperative study. JAMA, 256(11), 1449–1455.

    Article  Google Scholar 

  • Friedmann, P. D., Hoskinson Jr., R., Gordon, M., Schwartz, R., Kinlock, T., Knight, K., Flynn, P. M., Welsh, W. N., Stein, L. A., Sacks, S., & O’Connell, D. J. (2012). Medication-assisted treatment in criminal justice agencies affiliated with the criminal justice-drug abuse treatment studies (CJ-DATS): Availability, barriers, and intentions. Substance Abuse, 33(1), 9–18.

    Article  Google Scholar 

  • Fleetwood, J., Radcliffe, P., & Stevens, A. (2015). Shorter sentences for drug mules: The early impact of the sentencing guidelines in England and Wales. Drugs: Education, Prevention and Policy, 22(5), 428–436.

    Google Scholar 

  • Gordon, M. S., Vocci, F. J., Fitzgerald, T. T., O’Grady, K. E., & O’Brien, C. P. (2017). Extended-release naltrexone for pre-release prisoners: A randomized trial of medical mobile treatment. Contemporary Clinical Trials, 53, 130–136.

    Article  Google Scholar 

  • Haile, C. N., & Kosten, T. R. (2013). Pharmacotherapy for stimulant-related disorders. Current Psychiatry Reports, 15(11), 415.

  • Hammett, T. M. (2006). HIV/AIDS and other infectious diseases among correctional inmates: transmission, burden, and an appropriate response. American Journal of Public Health, 96(6), 974–978.

  • Lee, J. D., Friedmann, P. D., Kinlock, T. W., Nunes, E. V., Boney, T. Y., Hoskinson Jr., R. A., et al. (2016). Extended-release naltrexone to prevent opioid relapse in criminal justice offenders. New England Journal of Medicine, 374(13), 1232–1242.

    Article  Google Scholar 

  • Ling, W., & Wesson, D. R. (1984). Naltrexone for healthcare professionals: A collaborative private practice experience. Journal of Clinical Psychiatry, 45, 46–48.

  • McDonald, R. D., Tofighi, B., Laska, E., Goldfeld, K., Bonilla, W., Flannery, M., et al. (2016). Extended-release naltrexone opioid treatment at jail re-entry (XOR). Contemporary Clinical Trials, 49, 57–64.

    Article  Google Scholar 

  • Merrall, E. L., Kariminia, A., Binswanger, I. A., Hobbs, M. S., Farrell, M., Marsden, J., Hutchinson, S. J. & Bird, S. M. (2010). Meta‐analysis of drug‐related deaths soon after release from prison. Addiction, 105(9), 545–1554.

  • Minozzi, S., Amato, L., Vechi, S., Davoili, M., Kirchmayer, U., & Verster, A. (2011). Oral naltrexone maintenance treatment for opioid dependence. Cochrane Database of Systematic Reviews (4):CD001333. doi:10.1002/14651858.CD001333.pub4.

  • Mooney, L. J., Hillhouse, M. P., Thomas, C., Ang, A., Sharma, G., Terry, G., Chang, L., Walker, R., Trivedi, M., Croteau, D. & Sparenborg, S., (2016). Utilizing a Two-stage Design to Investigate the Safety and Potential Efficacy of Monthly Naltrexone Plus Once-daily Bupropion as a Treatment for Methamphetamine Use Disorder. Journal of Addiction Medicine, 10(4), 236–243.

  • Oliva, E. M., Maisel, N. C., Gordon, A. J., & Harris, A. H. (2011). Barriers to use of pharmacotherapy for addiction disorders and how to overcome them. Current Psychiatry Reports, 13(5), 374–381.

    Article  Google Scholar 

  • Passarino, G., Ciccone, G., Siragusa, R., Tappero, P., & Mollo, F. (2005). Histopathological findings in 851 autopsies of drug addicts, with toxicologic and virologic correlations. The American Journal of Forensic Medicine and Pathology, 26(2), 106–116.

    Google Scholar 

  • Prendergast, M. L., Campos, M., Farabee, D., Evans, W. K., & Martinez, J. (2004). Reducing substance use in prison: The California Department of Corrections drug reduction strategy project. The Prison Journal, 84(2), 265–280.

    Article  Google Scholar 

  • Rawson, R. R., McCann, M. J., HJasson, A. J., & Ling, W. (2000). Addiction pharmacotherapy 2000: New options, new challenges. Journal of Psychoactive Drugs, 32(4), 371–378.

    Article  Google Scholar 

  • Reed, K., Day, E., & Strang, J. (2015). Pharmacological treatments for drug misuse and dependence. Expert Opinion on Pharmacotherapy, 16(3), 325–333.

    Google Scholar 

  • Roman, P. M., Abraham, A. J., & Knudsen, H. K. (2011). Using medication-assisted treatment for substance use disorders: Evidence of barriers and facilitators of implementation. Addictive Behaviors, 36(6), 584–589.

    Article  Google Scholar 

  • Rösner, S., Hackl-Herrwerth, A., Leucht, S., Vecchi, S., Srisurapanont, M., & Soyka, M. (2010). Opioid antagonists for alcohol dependence. Cochrane Database System Review, 8(12), CD001867

  • Shearer, J., Wodak, A. D., & Dolan, K. A. (2007). Evaluation of a prison-based naltrexone program. International Journal of Prisoner Health, 3(3), 214–224.

    Article  Google Scholar 

  • Stein, M. D., & Anderson, B. (2003). Injection frequency mediates health service use among persons with a history of drug injection. Drug and Alcohol Dependence, 70(2), 159–168.

    Article  Google Scholar 

  • Tambour, S., & Quertemont, E. (2007). Preclinical and clinical pharmacology of alcohol dependence. Fundamental & Clinical Pharmacology, 21(1), 9–28.

    Article  Google Scholar 

  • Thomas, C. P., Fullerton, C. A., Kim, M., Montejano, L., Lyman, D. R., Dougherty, R. H., et al. (2014). Medication-assisted treatment with buprenorphine: Assessing the evidence. Psychiatric Services, 65(2), 158–170.

    Article  Google Scholar 

  • Tompkins, C. N. E., Wright, N. M. J., Waterman, M. G., & Sheard, L. (2009). Exploring prison buprenorphine misuse in the United Kingdom: A qualitative study of former prisoners. International Journal of Prisoner Health, 5(2), 71–87.

    Article  Google Scholar 

  • Weiss, R. D. (2004). Adherence to pharmacotherapy in patients with alcohol and opioid dependence. Addiction, 99(11), 1382–1392.

    Article  Google Scholar 

  • World Health Organization (2014). Global status report on alcohol and health. Geneva: WHO Press.

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Farabee, D. Current and Promising Pharmacotherapies for Substance Use Disorders among Justice-Involved Populations. Eur J Crim Policy Res 24, 145–153 (2018). https://doi.org/10.1007/s10610-017-9349-y

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