A series of novel isosteviol-derived alkenyl ethers were synthesized and structurally characterized by IR, NMR, and HR-MS. The tested compounds are more sensitive to Gram-positive bacteria than to Gram-negative bacteria. In particular, compound 5 exhibited better bacteriostatic activity against B. subtilis with a minimum inhibitory concentration of 2.403 mM, whereas compounds 8 and 10 selectively inhibited the S. aureus strain.
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Acknowledgment
We are grateful for financial support from the Key Scientific and Technological Project of Henan Province (Project No. 222102310480), the Project of Fundamental Researches and Applied Fundamental Researches of Zhengzhou Science and Technology Bureau (zkz202102), and the High Level Talent Fund (Project No. 20180060) of Zhengzhou Institute of Technology, China.
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Published in Khimiya Prirodnykh Soedinenii, No. 5, September–October, 2022, pp. 723–726.
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Liu, CJ., Yu, ZY., Min, YT. et al. Synthesis, Structure, and Antibacterial Activities of Diterpenoid Isosteviol-Derived Alkenyl Ethers. Chem Nat Compd 58, 857–861 (2022). https://doi.org/10.1007/s10600-022-03816-5
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DOI: https://doi.org/10.1007/s10600-022-03816-5