Skip to main content
SpringerLink
Log in

A New N-cis-Coumaroyltyramine Derivative from Fissistigma oldhamii

  • Published:
Chemistry of Natural Compounds Aims and scope

A new N-cis-coumaroyltyramine derivative, fissistyramine (1), along with four known coumaroyltyramine derivatives (2–5), was isolated from the stems of Fissistigma oldhamii (Hemsl.) Merr. The structure of the new compound 1 was determined by 1D and 2D NMR as well as by HR-ESI-MS. The inhibitory effect of all the compounds on the proliferation of primary synovial cells was evaluated. Compounds 1, 2, and 5 exhibited inhibitory activity on synoviocytes, with IC50 values of 12.1, 13.8, and 15.6 μM.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1.

Similar content being viewed by others

References

  1. R. Y. Kuo, F. R. Chang, and Y. C. Wu, Chin. Pharm. J., 54, 155 (2002).

    CAS  Google Scholar 

  2. X. D. Hu, X. G. Zhong, X. H. Zhang, Y. N. Zhang, Z. P. Zheng, Y. Zhou, W. Tang, Y. Yang, Y. F. Yang, L. H. Hu, and J. P. Zuo, Life Sci., 81, 1677 (2007).

    Article  CAS  Google Scholar 

  3. Y. N. Zhang, X. G. Zhong, Z. P. Zheng, X. D. Hu, J. P. Zuo, and L. H. Hu, Bioorg. Med. Chem., 15, 988 (2007).

    Article  CAS  Google Scholar 

  4. G. S. Firestein and N. J. Zvaifler, Arthritis Rheum., 46 (2), 298 (2002).

    Article  CAS  Google Scholar 

  5. P. Hasler and M. Zouali, FASEB J., 5 (12), 2085 (2001).

    Article  Google Scholar 

  6. E. M. Shevach, Arthritis Rheum., 50 (9), 2721 (2004).

    Article  CAS  Google Scholar 

  7. I. Wicks, G. McColl, and L. Harrison, Immunol. Today, 15, 533 (1994).

    Article  Google Scholar 

  8. X. M. Zhou, C. J. Zheng, Y. Q. Zhang, X. P. Zhang, X. P. Song, W. Xu, and G. Y. Chen, Planta Med., 83, 217 (2017).

    CAS  PubMed  Google Scholar 

  9. C. Zou, Q. Zhao, C. X. Chen, and Y. N. He, Chin. Chem. Lett., 10, 131 (1999).

    CAS  Google Scholar 

  10. K. Song, H. Q. Wang, C. Liu, J. Kang, B. M. Li, and R. Y. Chen, China J. Chin. Mater. Med., 39, 254 (2014).

    CAS  Google Scholar 

  11. T. Okuyama, S. Shibata, M. Hoson, T. Kawada, H. Osada, and T. Noguchi, Planta Med., 52, 171 (1986).

    Article  Google Scholar 

  12. A. A. El-Gamal, K. Takeya, H. Itokawa, A. F. Halim, M. M. Amer, H. A. Saad, and S. A. Awad, Nat. Med., 48, 304 (1994).

    CAS  Google Scholar 

Download references

ACKNOWLEDGMENT

This work was supported by the Hainan Province Natural Science Foundation (218QN234), the 973 Program, Ministry of Science and Technology of China (2014CB560714), the Hainan Province Natural Science Foundation of Innovative Research Team Project (2016CXTD007), and the Innovative Research Team Project of Ministry (IRT-16R19).

Author information

Authors and Affiliations

  1. Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, 571158, Haikou, P. R. China

    Cheng-Cong Zhu, Yu-Xi Luo, You Wu, Jing-Yu Yang, Xin-Shu Ji & Xue-Ming Zhou

  2. Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, 571158, Haikou, P. R. China

    Cheng-Cong Zhu, Yu-Xi Luo, You Wu, Jing-Yu Yang, Xin-Shu Ji & Xue-Ming Zhou

Authors
  1. Cheng-Cong Zhu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yu-Xi Luo
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. You Wu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jing-Yu Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Xin-Shu Ji
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Xue-Ming Zhou
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Xue-Ming Zhou.

Additional information

Published in Khimiya Prirodnykh Soedinenii, No. 5, September–October, 2021, pp. 714–715.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zhu, CC., Luo, YX., Wu, Y. et al. A New N-cis-Coumaroyltyramine Derivative from Fissistigma oldhamii. Chem Nat Compd 57, 832–834 (2021). https://doi.org/10.1007/s10600-021-03491-y

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10600-021-03491-y

Keywords

Search

Navigation