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A New Diterpenoid Against Endometrial Cancer from Sheareria nana

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Chemistry of Natural Compounds Aims and scope

A new diterpenoid, 15,16,17-trihydroxy,18-carboxylic acid 18-neo-clerodan-3,13-(Z)-diene was isolated from Sheareria nana S. Moore. The structure was elucidated by spectroscopic data. Compound 1 was evaluated for cytotoxic activities against human endometrial carcinoma cells (ECC-1). The results indicated that 1 showed moderate cytotoxic activity against ECC-1 cell lines with IC50 values of 5.6 ± 0.3 and 2.2 ± 0.2 μM for 24 and 48 h, respectively. Taken together, 1 was a good choice for the treatment of endometrial carcinoma.

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References

  1. C. Z. Gu, Z. Y. Li, S. Q. Huang, Y. Bao, Y. H. Li, P. S. Chen, Z. R. Zhang, S. K. Lai, and R. H. Shan, Flora of China, Vol. 80, Science Press, Beijing, 1999, p. 322.

    Google Scholar 

  2. O. Shulha and C. Zidorn, Phytochemistry, 163, 149 (2019).

    Article  CAS  Google Scholar 

  3. D. E. Dusmatova, K. K. Turgunov, Kh. M. Bobakulov, R. F. Mukhamatkhanova, I. D. Sham’yanov, B. Tashkhodzhaev, and N. D. Abdullaev, Chem. Nat. Compd., 56, 852 (2020).

    Article  CAS  Google Scholar 

  4. K. Mahadeo, I. Grondin, G. Herbette, T. L. Palama, N. Bouchemal, J. Soulange, S. J. Laulloo, J. Sadeyen, L. Humeau, M. Frederich, A. Gauvin-Bialecki, and H. Kodja, Phytochemistry, 176, 112401 (2020).

    Article  CAS  Google Scholar 

  5. Z. Y. Tang, J. M. Shen, F. Zhang, J. Y. Liang, and Z. X. Xia, Fitoterapia, 124, 12 (2018).

    Article  CAS  Google Scholar 

  6. D. A. Cifuente, E. J. Borkowski, M. E. Sosa, J. C. Gianello, O. S. Giordano, and C. E. Tonn, Phytochemistry, 61, 899 (2002).

    Article  CAS  Google Scholar 

  7. T. S. Martin, K. Ohtani, R. Kasai, and K. Yamasaki, Phytochemistry, 42, 153 (1996).

    Article  CAS  Google Scholar 

  8. B. Das, M. R. Reddy, R. Ramu, N. Ravindranath, H. Harish, K. V. S. Y. Ramakrishna, K. Rao, K. Harakishore, and U. S. N. Murthy, Phytochemistry, 66, 633 (2005).

    Article  CAS  Google Scholar 

  9. M. Gavagnin, M. Carbone, P. Amodeo, E. Mollo, R. M.Vitale, V. Roussis, and G. Cimino, J. Org. Chem., 72, 5625 (2007).

    Article  CAS  Google Scholar 

  10. Z. Y. Tang, L. H. Lu, and Z. X. Xia, Drug. Des. Dev. Ther., 14, 3965 (2020).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Emergency and Critical Care Medicine, JinShan Hospital, Fudan University, Shanghai, 201508, P. R. China

    Zhongyan Tang

  2. Department of Pharmacy, School & Hosipital of Stomatology, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Tongji University, 399 Middle Yan Chang Road, 200072, Shanghai, P. R. China

    Zhengxiang Xia

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  1. Zhongyan Tang
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  2. Zhengxiang Xia
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Correspondence to Zhengxiang Xia.

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Published in Khimiya Prirodnykh Soedinenii, No. 4, July–August, 2021, pp. 590–592.

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Tang, Z., Xia, Z. A New Diterpenoid Against Endometrial Cancer from Sheareria nana. Chem Nat Compd 57, 691–694 (2021). https://doi.org/10.1007/s10600-021-03451-6

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  • DOI: https://doi.org/10.1007/s10600-021-03451-6

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