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Chemical Constituents of Microalgae Tetraselmis convolutae

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The first chemical investigation of the marine microalgae Tetraselmis convolutae is reported. Two phytyl esters, phytyl hexadeca-4,7-10,13-tetraenoate (1) and phytyl palmitate (2), and five other compounds, including phytol (3), hexadeca-4,7-10,13-tetraenoic acid (4), poriferasterol (5), palmitic acid (6), and glycerol (7), were isolated from the extracts of Tetraselmis convolutae. Compound 1 was isolated from nature for the first time, and it showed significant cytotoxic activity against KB, SK-LU-1, MCF7, and HepG2 cancer cell lines with IC50 values in the range of 65.23 ± 6.17–89.81 ± 5.83 μM/mL.

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Acknowledgment

The authors would like to express their thanks for the grants and financial support received from the Vietnam Academy of Science and Technology (Code: VAST.TD.DLB.07/16-18).

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Authors and Affiliations

  1. Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam

    Nguyen Thi Minh Hang, Tran Huu Giap, Le Nguyen Thanh & Chau Van Minh

  2. Institute of Biotechnology, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam

    Dang Diem Hong & Ngo Thi Hoai Thu

Authors
  1. Nguyen Thi Minh Hang
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  2. Tran Huu Giap
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  3. Le Nguyen Thanh
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  4. Dang Diem Hong
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  5. Ngo Thi Hoai Thu
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  6. Chau Van Minh
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Correspondence to Nguyen Thi Minh Hang.

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Published in Khimiya Prirodnykh Soedinenii, No. 5, September–October, 2019, pp. 689–692.

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Hang, N.T.M., Giap, T.H., Thanh, L.N. et al. Chemical Constituents of Microalgae Tetraselmis convolutae. Chem Nat Compd 55, 797–801 (2019). https://doi.org/10.1007/s10600-019-02817-1

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