Two new chalcones, 2′,4-hydroxy-3,4′-dimethoxychalcone ( 1 ) and 2′,3-hydroxy-4,4′-dimethoxychalcone ( 2 ), together with four known chalcones ( 3–6 ), were isolated from the whole plant of Desmodium podocarpum. All of their structures were determined by spectroscopic methods including 1D and 2D NMR. Compounds 1 and 2 were evaluated for their cytotoxicity using five tumor cell lines. Compound 1 exhibited cytotoxicity against SHSY5Y and PC3 cells with IC 50 values of 3.8 and 3.6 μM, and compound 2 exhibited cytotoxicity against A549 cells with IC 50 value of 3.5 μM, respectively.
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Acknowledgment
This research was supported by the National Natural Science Foundation of China (No. 21032085), the excellent Scientific and Technological Team of Yunnan High School (2010CI08), the Yunnan University of Nationalities Green Chemistry and Functional Materials Research for Provincial Innovation Team (2011HC008), and the Open Research Fund Program of Key Laboratory of Ethnic Medicine Resource Chemistry (Yunnan University of Nationalities) (2010XY08).
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Published in Khimiya Prirodnykh Soedinenii, No. 6, November–December, 2015, pp. 915–918.
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Qin, Y., Yang, YC., Meng, YL. et al. Chalcones from Desmodium podocarpum and Their Cytotoxicity. Chem Nat Compd 51, 1062–1066 (2015). https://doi.org/10.1007/s10600-015-1492-4
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DOI: https://doi.org/10.1007/s10600-015-1492-4