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Chemical Constituents of Metabolites Produced by the Actinomycete Acrocarpospora punica

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One new γ-butyrolactone derivative, acrocarpunilactone (1), was isolated and identified from the rice solidsubstrate fermentation culture of an actinomycete, Acrocarpospora punica, together with nine known compounds, hydroxychavicol acetate (2), 4-allylcatechol (3), trans-caffeic aldehyde (4), (–)-ent-4β-hydroxy-10α-methoxyaromadendrane (5), (6α,7α)-4β-hydroxy-10α-methoxyaromadendrane (6), futoamide (7), N-[8′-(4′-hydroxyphenylethyl)]-2-hydroxybenzoylamide (8), hemiariensin (9), and 3-ethyl-4-hydroxybenzoic acid (10). Furthermore, the inhibitory effects of some isolates (compounds 1–6) on nitric oxide (NO) production in lipopolysaccharide (LPS)-activated macrophages were also evaluated. Compounds 1–3 showed stronger inhibition on NO production than the positive control quercetin.

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Acknowledgment

This investigation was supported by a Grant from the Ministry of Economic Affairs of the Republic of China. The authors also thank Senior Technician Mrs. Chyi-Jia Wang of the Center for Resources, Research and Development (CRRD) of Kaohsiung Medical University for measuring the 2D NMR data.

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Authors and Affiliations

  1. Bioresource Collection and Research Center (BCRC), Food Industry Research and Development Institute (FIRDI), Hsinchu, 300, Taiwan

    Ming-Jen Cheng, Min Tseng & Gwo-Fang Yuan

  2. Natural Chemical Ind. Co. Ltd, Changhua, 500, Taiwan

    Yen-Chen Cheng

  3. School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University (CMU), Taichung, 404, Taiwan

    Ming-Tsuen Hsieh

  4. Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University (KMU), Kaohsiung, 807, Taiwan

    Ih-Sheng Chen & Hsun-Shuo Chang

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  1. Ming-Jen Cheng
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  2. Yen-Chen Cheng
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  3. Ming-Tsuen Hsieh
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  4. Ih-Sheng Chen
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  5. Min Tseng
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  6. Gwo-Fang Yuan
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  7. Hsun-Shuo Chang
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Correspondence to Ming-Jen Cheng.

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Published in Khimiya Prirodnykh Soedinenii, No. 4, July–August, 2014, pp. 528–531.

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Cheng, MJ., Cheng, YC., Hsieh, MT. et al. Chemical Constituents of Metabolites Produced by the Actinomycete Acrocarpospora punica . Chem Nat Compd 50, 606–610 (2014). https://doi.org/10.1007/s10600-014-1034-5

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  • DOI: https://doi.org/10.1007/s10600-014-1034-5

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