Two high-molecular-weight (>1000 kDa) water-soluble biopolymers, the main component of which was poly[3-(3,4-dihydroxyphenyl)glyceric acid] or poly[oxy-1-carboxy-2-(3,4-dihydroxyphenyl)ethylene] according to IR and NMR spectroscopy, were isolated from roots of Symphytum officinale. They exhibit antioxidant activity as expressed in a decrease of active oxygen species (AOS) by interfering directly in their formation process by polymorphonuclear neutrophils (PMN) and binding directly AOS.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
F. M. van den Dungen, Symphytum officinale L. - Influence on immune functions and wound-healing processes, Ph.D. Thesis, University of Utrecht (1993).
V. V. Barbakadze, E. P. Kemertelidze, A. S. Shashkov, and A. I. Usov, Mendeleev Commun., 10, 148 (2000).
V. V. Barbakadze, E. P. Kemertelidze, I. L. Targamadze, A. S. Shashkov, and A. I. Usov, Bioorg. Khim., 28, 362 (2002).
V. Barbakadze, E. Kemertelidze, I. Targamadze, K. Mulkijanyan, A. S. Shashkov, and A. I. Usov, Molecules, 10, 1135 (2005).
V. Barbakadze, E. Kemertelidze, I. Targamadze, K. Mulkidzhanyan, J. Kemmink, A. J. J. van den Berg, K. J. Beukelman, and A. I. Usov, Khim. Prir. Soedin., 303 (2005).
V. V. Barbakadze, E. P. Kemertelidze, A. I. Usov, B. H. Kroes, H. C. Quarles van Ufford, E. van den Worm, C. J. Beukelman, A. J. J. van den Berg, and R. P. Labadie, Proc. Georgian Acad. Sci. Biol. Ser., 25, 207 (1999).
C. M. Barthomeuf, E. Debiton, V. V. Barbakadze, and E. P. Kemertelidze, J. Agric. Food Chem., 49, 3942 (2001).
V. Barbakadze, E. Kemertelidze, K. Mulkidzhanyan, A. J. J. van den Berg, C. J. Beukelman, E. van den Worm, H. C. Quarles van Ufford, and A. I. Usov, Khim.-farm. Zh., 41, 14 (2007).
M. B. Hampton, J. Kettle, and C. Winterbourn, Blood, 92, 3007 (1998).
S. J. Weiss, N. Engl. J. Med., 320, 365 (1989).
H. L. Malech and J. I. Gallin, N. Engl. J. Med., 317, 687 (1987).
B. Latha and M. Babu, Burns, 27, 309 (2001).
V. V. Barbakadze, R. A. Gakhokidze, Z. S. Shengeliya, and A. I. Usov, Khim. Prir. Soedin., 330 (1989).
J. C. Whitin, D. H. Ryan, and H. J. Cohen, Blood, 66, 1182 (1985).
N. Schnitzler, K. Schwezer, A. Podbielski, G. Haase, B. Spellerberg, R. Holland, and R. Lutticken, Adv. Exp. Med. Biol., 418, 897 (1997).
C. Dahlgren, P. Follin, A. Jiohansson, R. Lock, and K. Orselius, J. Biolumin. Chemilumin., 4, 263 (1989).
C. Dahlgren, H. Aniansson, and K. E. Magnusson, Infect. Immun., 47, 326 (1985).
E. van den Worm, C. J. Beukelman, A. J. J. van den Berg, B. H. Kroes, R. P. Labadie, and H. van Dijk, Eur. J. Pharmacol., 433, 225 (2001).
J. M. McCord and I. Fridovich, J. Biol. Chem., 243, 5753 (1968).
H. C. Chiang, Y. J. Lo, and F. J. Lu, J. Enzyme Inhib., 8, 61 (1994).
J. E. Chung, M. Kurisawa, Y.-J. Kim, et al., Biomacromolecules, 5, 113 (2004).
W. Yaphe and G. P. Arsenault, Anal. Biochem., 13, 143 (1965).
N. Blumenkrantz and G. Asboe-Hansen, Anal. Biochem. 54, 484 (1973).
J. P. A. M. Klerx, C. J. Beukelman, H. van Dijk, and H. J. M. N. Willers, J. Immunol. Methods, 63, 215 (1983).
J. M. Simons, L. A. 't Hart, H. van Dijk, F. C. Fischer, K. T. D. de Silva, and R. P. Labadie, J. Ethnopharmacol., 26, 169 (1989).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 9–12, January–February, 2009.
Rights and permissions
About this article
Cite this article
Barbakadze, V., van den Berg, A.J.J., Beukelman, C.J. et al. Poly[3-(3,4-dihydroxyphenyl)glyceric acid] from Symphytum officinale roots and its biological activity. Chem Nat Compd 45, 6–10 (2009). https://doi.org/10.1007/s10600-009-9221-5
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10600-009-9221-5