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Five unusual natural carbohydrates from Actinosynnema pretiosum

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Chemistry of Natural Compounds Aims and scope

Five unusual hexose derivatives were isolated from the carbohydrate portion of the solid-state fermentation extract of Actinosynnema pretiosum ssp. auranticum ATCC 31565, which is a producing strain of maytansinoids that are a family of 19-membered macrocyclic lactams having extraordinary cytotoxic and antineoplastic activities. Their structures were determined to be 2-deoxy-α-D-arabino-hexopyranose (1), 2-deoxy-β-D-arabino-hexopyranose (2), 3,6-anhydro-2-deoxy-α-D-arabino-hexcofuranose (3), 3,6-anhydro-2-deoxy-β-D-arabino-hexofuranose (4), and 2-(D-glycerol-1,2-dihydroxyethyl)furan (5) by NMR spectroscopic experiments.

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Acknowledgment

This work was partially supported by the National Science Fund for Distinguished Young Scholars to Y.-M. Shen (30325044), and the National Natural Science Foundation of China (30430020).

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Authors and Affiliations

  1. Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering; Xiamen Engineering Research Center of Marine Microbial Drug Discovery; Fujian Laboratory of Pharmaceutical Engineering; School of Life Science, Xiamen University, Xiamen, Fujian, 361005, P. R. China

    Chunhua Lu & Yuemao Shen

  2. Bio-X Life Science Research Center, Shanghai Jiaotong University, Shanghai, 200030, China

    Linquan Bai

Authors
  1. Chunhua Lu
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  2. Linquan Bai
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  3. Yuemao Shen
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Correspondence to Yuemao Shen.

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Published in Khimiya Prirodnykh Soedinenii, No. 5, pp. 481–483, September-October, 2008.

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Lu, C., Bai, L. & Shen, Y. Five unusual natural carbohydrates from Actinosynnema pretiosum . Chem Nat Compd 44, 594–597 (2008). https://doi.org/10.1007/s10600-008-9140-x

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  • DOI: https://doi.org/10.1007/s10600-008-9140-x

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