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Preparation of 2-unsubstituted 5-aryl(hetaryl)-1-hydroxy-1H-imidazoles from of 4-aryl(hetaryl)-1-hydroxy-2,5-dihydro-1H-imidazole-2-carboxylic acid 3-oxides

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Chemistry of Heterocyclic Compounds Aims and scope

Alkylaromatic 1-hydroxyamino-2-oximes reacted at the hydroxyamino group with glyoxylic acid hydrate, providing 4-aryl(hetaryl)-1-hydroxy-2,5-dihydro-1H-imidazole-2-carboxylic acid 3-oxides that were converted upon heating into 5-aryl(hetaryl)-1-hydroxy-1H-imidazoles containing a hydrogen atom at the heterocycle position 2.

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Authors and Affiliations

  1. N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9 Akademika Lavrentieva Ave., Novosibirsk, 630090, Russia

    Elena B. Nikolaenkova, Stanislav Yu. Grishchenko, Tatyana V. Rybalova & Alexei Ya. Tikhonov

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  1. Elena B. Nikolaenkova
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  2. Stanislav Yu. Grishchenko
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  3. Tatyana V. Rybalova
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  4. Alexei Ya. Tikhonov
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Correspondence to Alexei Ya. Tikhonov.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2023, 59(11/12), 752–757

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Nikolaenkova, E.B., Grishchenko, S.Y., Rybalova, T.V. et al. Preparation of 2-unsubstituted 5-aryl(hetaryl)-1-hydroxy-1H-imidazoles from of 4-aryl(hetaryl)-1-hydroxy-2,5-dihydro-1H-imidazole-2-carboxylic acid 3-oxides. Chem Heterocycl Comp 59, 752–757 (2023). https://doi.org/10.1007/s10593-024-03268-5

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