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Recent progress in the synthesis of morpholines

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Chemistry of Heterocyclic Compounds Aims and scope

The morpholine (1,4-oxazinane) motif attracted significant attention due to its widespread availability in natural products and biologically relevant compounds. This review describes recent advances in the synthesis of morpholines and their carbonyl-containing analogs from 1,2-amino alcohols, aziridines, epoxides, and related compounds. Special attention is paid to the syntheses performed in a stereoselective manner and using transition metal catalysis. Selected works published since 2013 are covered.

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Acknowledgement

Vitalii A. Palchykov would like to thank SAIA for funding and the National Scholarship Programme of the Slovak Republic for an individual scholarship.

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Authors and Affiliations

  1. Oles Honchar Dnipro National University, 72 Gagarin Ave., Dnipro, 49010, Ukraine

    Vitalii A. Palchykov

  2. State Scientific Institution “Institute for Single Crystals”, National Academy of Sciences of Ukraine, 60 Nauky Ave, Kharkiv, 61072, Ukraine

    Valentyn A. Chebanov

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  1. Vitalii A. Palchykov
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  2. Valentyn A. Chebanov
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Correspondence to Vitalii A. Palchykov.

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Published in Khimiya Geterotsiklicheskikh Soedinenii, 2019, 55(4/5), 324–332

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Palchykov, V.A., Chebanov, V.A. Recent progress in the synthesis of morpholines. Chem Heterocycl Comp 55, 324–332 (2019). https://doi.org/10.1007/s10593-019-02461-1

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  • DOI: https://doi.org/10.1007/s10593-019-02461-1

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