A mixture of pyridine-2-thiones and 2-amino-1-cyanoindolizines was obtained by condensation of N-[(alkoxycarbonyl)methyl]- or N-[(aroyl)-methyl]-2-chloro(bromo)pyridinium halides in the presence of 2 equivalents of triethylamine. Furthermore, reacting cyanoacetamide with N-[(alkoxycarbonyl)methyl]-2-chloro(bromo)pyridinium salts afforded a mixture of 2-amino-1-carbamoylindolizine-3-carboxylates and a novel heterocyclic system, 2,4-dioxo-2,3,4,5-tetrahydropyrido[1,2-d][1,4]diazepine-1-carbonitrile.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2015, 51(1), 56–59
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Tverdokhleb, N.M., Khoroshilov, G.E. Amide and thioamide of cyanoacetic acid in Аd N E type reactions with 2-halopyridinium salts. Chem Heterocycl Comp 51, 56–59 (2015). https://doi.org/10.1007/s10593-015-1659-8
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DOI: https://doi.org/10.1007/s10593-015-1659-8