A method for the preparation of 4-amino-substituted tetrahydropyrimido[4,5-d]azocines containing an aromatic pyrimidine fragment has been developed. It was established that tetrahydropyrido[4,3-d]pyri-midines are cleaved by the action of activated alkynes with the formation of 6-vinylpyrimidines.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1267-1274, August, 2013.
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Voskressensky, L.G., Ovcharov, M.V., Borisova, T.N. et al. Synthesis of 4-amino-substituted tetrahydropyrimido[4,5-d]azocines. Chem Heterocycl Comp 49, 1180–1187 (2013). https://doi.org/10.1007/s10593-013-1361-7
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DOI: https://doi.org/10.1007/s10593-013-1361-7