The synthesis of 3-allylthio-5H-[1,2,4]triazino[5,6-b]indole has been carried out by the reaction of 3-mercapto-5H-[1,2,4]triazino[5,6-b]indole with allyl bromide in the NaOH–H2O–DMSO system and in a one-pot synthesis from isatin-β-thiosemicarbazide. Halocyclization of allylthio-5H-[1,2,4]-triazino[5,6-b]indole synthesized the 3-halomethyl-3,10-dihydro-2H-[1,3]thiazolo[3',2':2,3][1,2,4]-triazino[5,6-b]indolium halides.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, 1107-1109, July, 2010.
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Kim, D.G., Zhuravlyova, A.V. Halocyclization of 3-allylthio-5H-[1,2,4]triazino[5,6-b]indole. Chem Heterocycl Comp 46, 896–898 (2010). https://doi.org/10.1007/s10593-010-0599-6
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DOI: https://doi.org/10.1007/s10593-010-0599-6