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Synthesis of methyl 6-aryl-5-(1H-benzimidazol-2-yl)-2-methylnicotinates

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Chemistry of Heterocyclic Compounds Aims and scope

A three-component cyclocondensation of 4-(dimethylamino)benzaldehyde, 2-phenacyl-1H-benz-imidazoles, and methyl 3-aminobut-2-enoate in refluxing acetic acid occurs via a Hantzsch type reaction and is accompanied by the loss of N,N-dimethylaniline to give the previously unknown methyl 6-aryl-5-(1H-benzimidazol-2-yl)-2-methylnicotinates.

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Authors and Affiliations

  1. Institute of Organic Chemistry National Academy of Sciences of Ukraine, Kiev, 02094, Ukraine

    I. B. Dzvinchuk & M. O. Lozinskii

Authors
  1. I. B. Dzvinchuk
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  2. M. O. Lozinskii
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Correspondence to I. B. Dzvinchuk.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1186–1192, August, 2009.

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Dzvinchuk, I.B., Lozinskii, M.O. Synthesis of methyl 6-aryl-5-(1H-benzimidazol-2-yl)-2-methylnicotinates. Chem Heterocycl Comp 45, 942–947 (2009). https://doi.org/10.1007/s10593-009-0370-z

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  • DOI: https://doi.org/10.1007/s10593-009-0370-z

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