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Brainstem Neuronal Circuitries Controlling Gastric Tonic and Phasic Contractions: A Review

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Abstract

This review is on how current knowledge of brainstem control of gastric mechanical function unfolded over nearly four decades from the perspective of our research group. It describes data from a multitude of different types of studies involving retrograde neuronal tracing, microinjection of drugs, whole-cell recordings from rodent brain slices, receptive relaxation reflex, accommodation reflex, c-Fos experiments, immunohistochemical methods, electron microscopy, transgenic mice, optogenetics, and GABAergic signaling. Data obtained indicate the following: (1) nucleus tractus solitarius (NTS)—dorsal motor nucleus of the vagus (DMV) noradrenergic connection is required for reflex control of the fundus; (2) second-order nitrergic neurons in the NTS are also required for reflex control of the fundus; (3) a NTS GABAergic connection is required for reflex control of the antrum; (4) a single DMV efferent pathway is involved in brainstem control of gastric mechanical function under most experimental conditions excluding the accommodation reflex. Dual-vagal effectors controlling cholinergic and non-adrenergic and non-cholinergic (NANC) input to the stomach may be part of the circuitry of this reflex. (5) GABAergic signaling within the NTS via Sst-GABA interneurons determine the basal (resting) state of gastric tone and phasic contractions. (6) For the vagal–vagal reflex to become operational, an endogenous opioid in the NTS is released and the activity of Sst-GABA interneurons is suppressed. From the data, we suggest that the CNS has the capacity to provide region-specific control over the proximal (fundus) and distal (antrum) stomach through engaging phenotypically different efferent inputs to the DMV.

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Fig. 1

Adapted from Fig. 13 of Ferreira et al. (2002)

Fig. 2

Adapted from Fig. 8b of Ferreira et al. (2005)

Fig. 3

Adapted from Fig. 11 of Ferreira et al. (2005)

Fig. 4
Fig. 5

Adapted from Fig. 2 of Herman et al. (2009)

Fig. 6

Adapted from Fig. 3 of Herman et al. (2009)

Fig. 7

Adapted from Fig. 5 of Herman et al. (2009)

Fig. 8

Adapted from Fig. 7a–c from Herman et al. (2009)

Fig. 9

Adapted from Fig. 9 of Herman et al. (2009)

Fig. 10
Fig. 11

Adapted from Fig. 2 of Lewin et al. (2016)

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Acknowledgements

RG expresses great appreciation to Gail J. Price for her wisdom and backing. This work was supported by the National Institutes of Health (NIDDK, United States) Grant R01-DK117508.

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  1. Department of Pharmacology and Physiology, Georgetown University Medical Center, Washington, DC, 20007, USA

    Richard A. Gillis, Ghazaul Dezfuli, Lorenza Bellusci, Stefano Vicini & Niaz Sahibzada

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  1. Richard A. Gillis
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  2. Ghazaul Dezfuli
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Correspondence to Stefano Vicini.

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Gillis, R.A., Dezfuli, G., Bellusci, L. et al. Brainstem Neuronal Circuitries Controlling Gastric Tonic and Phasic Contractions: A Review. Cell Mol Neurobiol 42, 333–360 (2022). https://doi.org/10.1007/s10571-021-01084-5

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