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Antibacterial and wound healing activities of silver nanoparticles embedded in cellulose compared to other polysaccharides and protein polymers

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Abstract

The aggregation of silver nanoparticles (AgNPs) in colloidal solution and the oxidative cytotoxicity towards human cells are two major hindrances for their thriving medicinal applications. Their incorporation in natural polymers such as cellulose, chitosan, alginate, collagen, gelatin, silk fibroin, carrageenan, curdlan, hyaluronic acid, keratin and starch may be an alluring alternative strategy to sidestep these complications and attain advantageous wound dressings. Biocompatibility, bioavailability, biodegradability, and inherent therapeutic properties known for such polymers, would accelerate the healing of infected chronic wounds. However, the low thermal stability, mechanical strength, rapid biodegradation, and weak washing resistance properties are some of the limitations for these polymers. Herein, recent advances, present challenges, and future perspectives for AgNPs-incorporated nanocomposites (NCs) are discussed to realize the ideal antibacterial activities by exploiting the abundant natural biopolymers.

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Authors and Affiliations

  1. Nanobiotechnology Laboratory, Biology Department, Faculty of Science, Razi University, Kermanshah, Iran

    Mehran Alavi

  2. Regional Centre of Advanced Technologies and Materials, Czech Advanced Technology and Research Institute, Palacky University, Šlechtitelů 27, 783 71, Olomouc, Czech Republic

    Rajender S. Varma

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  1. Mehran Alavi
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  2. Rajender S. Varma
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Correspondence to Mehran Alavi or Rajender S. Varma.

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Alavi, M., Varma, R.S. Antibacterial and wound healing activities of silver nanoparticles embedded in cellulose compared to other polysaccharides and protein polymers. Cellulose 28, 8295–8311 (2021). https://doi.org/10.1007/s10570-021-04067-3

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