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Calcium functioned carboxymethylated cotton fabric for hemostatic wound dressing

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Abstract

Massive hemorrhage is a frequent cause of human death in the operating room and other emergency situations. Therefore, effective hemostatic wound dressings are essential to save lives. Here we show that, calcium functioned carboxymethylated cotton fabric (MCF-Ca) conveniently prepared by carboxymethylation of cotton fabrics followed by treatment with calcium chloride solution could serve as an effective hemostatic wound dressing. The calcium content of MCF-Ca was determined as 18.11 ± 0.44 mg/g, and the calcium ions were released into a saline solution, a process that reached near-equilibrium within about 2 min. The biocompatible MCF-Ca promoted hemostasis via forming complexes with blood cells, and it showed lower blood clotting index as well as shorter blood clotting time comparing with unmodified CF in vitro. In addition, MCF-Ca exhibited better hemostatic efficiency than CF in vivo, resulting in much shorter hemostasis time and less blood loss in rat liver injury model and femoral artery animal model. In conclusion, MCF-Ca shows good potential to be used as wound dressing for patients with uncontrolled or massive hemorrhage.

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Acknowledgments

The authors thanks Zeju Yan and Rui Zhang for their contributions to this study. The present work is supported by the Fundamental Research Funds for the Central Universities (No. 2232020G-04), National Key R & D Program of China (No. 2018YFC1801502), the Fundamental Research Funds for the Central Universities and Graduate Student Innovation Fund of Donghua University (No. CUSF-DH-D-2020066), and the National Natural Science Foundation of China (No. 81900604).

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Authors and Affiliations

  1. Key Lab of Science and Technology of Eco-textile, Ministry of Education, College of Chemistry, Chemical Engineering and Biotechnology, Innovation Center for Textile Science and Technology, Donghua University, No. 2999 North Renmin Road, Shanghai, 201620, China

    Yamei Wang, Peiwen Zhou, Yujun Liu, Yi Zhong, Bijia Wang, Linping Zhang, Zhize Chen, Xiaofeng Sui, Xueling Feng, Hong Xu & Zhiping Mao

  2. Department of Urology and Andrology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200001, China

    Dongdong Xiao

  3. Shanghai Key Laboratory of Tissue Engineering, Shanghai Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200011, China

    Dongdong Xiao

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  1. Yamei Wang
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  2. Peiwen Zhou
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  3. Dongdong Xiao
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  4. Yujun Liu
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  5. Yi Zhong
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  9. Xiaofeng Sui
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  10. Xueling Feng
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  11. Hong Xu
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  12. Zhiping Mao
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Correspondence to Hong Xu or Zhiping Mao.

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Wang, Y., Zhou, P., Xiao, D. et al. Calcium functioned carboxymethylated cotton fabric for hemostatic wound dressing. Cellulose 27, 10139–10149 (2020). https://doi.org/10.1007/s10570-020-03479-x

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