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Stem cell regenerative potential for plastic and reconstructive surgery

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Abstract

Stem cells represent heterogeneous population of undifferentiated cells with unique characteristics of long term self renewal and plasticity. Moreover, they are capable of active migration to diseased tissues, secretion of different bioactive molecules, and they have immunosuppressive potential as well. They occur in all tissues through life and are involved in process of embryogenesis and regeneration. During last decades stem cells attracted significant attention in each field of medicine, including plastic and reconstructive surgery. The main goal of the present review article is to present and discuss the potential of stem cells and to provide information about their safe utilization in chronic wounds and fistulae healing, scar management, breast reconstruction, as well as in bone, tendon and peripheral nerve regeneration.

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Acknowledgments

Received from Ministry of Health of the Slovak republic (Registration number: 2012/4-UKBA-4) and Slovak Research and Development Agency (Registration number: APVV-14-0032).

Author’s contribution

MB designed, organized, and prepared the manuscript from the initial draft to final version. MC participated in manuscript preparation. IK participated in manuscript preparation. RZ was involved in manuscript design, organization and preparation. JF participated in manuscript preparation. JK participated in manuscript preparation.

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Authors and Affiliations

  1. Department of Plastic, Reconstructive and Aesthetic Surgery, Faculty of Medicine, Comenius University in Bratislava and University Hospital, Pažítkova 4, 826 06, Bratislava, Slovakia

    Martin Boháč & Jozef Fedeleš

  2. Institute of Histology and Embryology, Faculty of Medicine, Comenius University in Bratislava, Bratislava, Slovakia

    Mária Csöbönyeiová

  3. Department of the Oromaxillofacial Surgery, Faculty of Medicine, Comenius University in Bratislava and University Hospital, Bratislava, Slovakia

    Ida Kupcová

  4. Department of Orthopaedics, Faculty of Medicine, Comenius University in Bratislava and Children’s University Hospital, Bratislava, Slovakia

    Radoslav Zamborský

  5. Department of Burn Surgery and Reconstructive Surgery, Faculty of Medicine, Comenius University in Bratislava and University Hospital, Bratislava, Slovakia

    Ján Koller

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  1. Martin Boháč
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  2. Mária Csöbönyeiová
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  3. Ida Kupcová
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  4. Radoslav Zamborský
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  5. Jozef Fedeleš
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  6. Ján Koller
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Correspondence to Martin Boháč.

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Boháč, M., Csöbönyeiová, M., Kupcová, I. et al. Stem cell regenerative potential for plastic and reconstructive surgery. Cell Tissue Bank 17, 735–744 (2016). https://doi.org/10.1007/s10561-016-9583-4

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