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The Function of Circular RNAs in Myocardial Ischemia–Reperfusion Injury: Underlying Mechanisms and Therapeutic Advancement

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Abstract

Myocardial ischemia reperfusion injury (MIRI) represents a prevalent and severe cardiovascular condition that arises primarily after myocardial infarction recanalization, cardiopulmonary bypass surgery, and both stable and unstable angina pectoris. MIRI can induce malignant arrhythmias and heart failure, thereby increasing the morbidity and mortality rates associated with cardiovascular diseases. Hence, it is important to assess the potential pathological mechanisms of MIRI and develop effective treatments. The role of circular RNAs (circRNAs) in MIRI has increasingly become a topic of interest in recent years. Moreover, significant evidence suggests that circRNAs play a critical role in MIRI pathogenesis, thereby representing a promising therapeutic target. This review aimed to provide a comprehensive overview of the current understanding of the role of circRNAs in MIRI and discuss the mechanisms through which circRNAs contribute to MIRI development and progression, including their effects on apoptosis, inflammation, oxidative stress, and autophagy. Furthermore, the potential therapeutic applications of circRNAs in MIRI treatment, including the use of circRNA-based therapies and modulation of circRNA expression levels, have been explored. Overall, this paper highlights the importance of circRNAs in MIRI and underscores their potential as novel therapeutic targets.

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Funding

This work was supported by grant from the National Natural Science foundation of China (No.82170286; No.81960051); Construction Funding from Characteristic Key Laboratory of Guizhou Province, No. [2021]313.

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  1. Department of Cardiovascular Surgery, the Affiliated Hospital of Guizhou Medical University, Beijing Road, Yunyan District, Guiyang, 550001, Guizhou Province, China

    Kai-Yuan Chen, Si-Yuan Yang, Xuan-Yi Hu & Gui-You Liang

  2. Translational Medicine Research Center, Guizhou Medical University, Guiyang, 550025, Guizhou Province, China

    Kai-Yuan Chen, Zhou Liu, Jun-Hou Lu & Gui-You Liang

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The conceptualization of this review was spearheaded by Kaiyuan Chen, while Junhou Lu and Guiyou Liang conducted an extensive literature search. Kaiyuan Chen took the lead in drafting the manuscript, with critical editing contributions from Zhou Liu and Guiyou Liang. Hu Xuanyi and Yang Siyuan are responsible for language proofreading. All authors diligently reviewed and provided their approval for the final version of the manuscript.

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Correspondence to Gui-You Liang.

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Chen, KY., Liu, Z., Lu, JH. et al. The Function of Circular RNAs in Myocardial Ischemia–Reperfusion Injury: Underlying Mechanisms and Therapeutic Advancement. Cardiovasc Drugs Ther (2024). https://doi.org/10.1007/s10557-024-07557-1

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