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Effects of Long-Term Treatment with Candesartan on Hemodynamics and Organ Damage in Spontaneously Hypertensive Rats

  • Basic Pharmacology
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Summary

This study was designed to investigate the effects of candesartan on blood pressure (BP) and blood pressure variability (BPV) reductions, baroreflex sensitivity (BRS) amelioration, and organ protection in spontaneously hypertensive rats (SHR). Methods: Studies were performed in two groups of SHR (n = 13 for control rats; and n = 20 for candesartan-treated rats) and one group of WKY rats (n = 13). Candesartan (3mg /kg/d) was given in rat chow for 4 months. BP was then continuously recorded for 24 hours in conscious state. After the determination of BRS, rats were killed for organ-damage evaluation. Results: Long-term treatment with candesartan significantly reduced BP and BPV expressed by both standard deviation and variation coefficient of BP, enhanced BRS and produced obvious organ protection. Compared with BP level, BPV and BRS values showed a closer or similar relationship with organ-damage parameters in SHR. Multiple regression analysis showed that the decrease in left ventricular hypertrophy was most closely associated with the increase in BRS, whereas the decrease in aortic hypertrophy was most closely associated with the decrease in 24-hour systolic BPV, and the amelioration in renal lesions, with the increase in BRS and the decrease in 24-hour systolic BPV. Conclusion: long-term treatment with candesartan results in organ protection in SHR. Besides BP reduction, the decrease in BPV and the restoration of BRS are significantly related to this organ protection.

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Authors and Affiliations

  1. Department of Pharmacology, Second Military Medical University, Shanghai, China

    He-Hui Xie, Yuan-Yuan Chen, Chao-Yu Miao, Fu-Ming Shen & Ding-Feng Su

  2. Department of Pharmacology, Second Military Medical University, 325 Guo He Road, Shanghai, 200433, China

    Ding-Feng Su

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  1. He-Hui Xie
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  2. Yuan-Yuan Chen
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  3. Chao-Yu Miao
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  4. Fu-Ming Shen
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  5. Ding-Feng Su
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Correspondence to Ding-Feng Su.

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Xie, HH., Chen, YY., Miao, CY. et al. Effects of Long-Term Treatment with Candesartan on Hemodynamics and Organ Damage in Spontaneously Hypertensive Rats. Cardiovasc Drugs Ther 19, 391–397 (2005). https://doi.org/10.1007/s10557-005-5734-8

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