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Intracranial Bleeding Associated with Clopidogrel

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Abstract

Clopidogrel is an effective antiplatelet agent and is useful in the prevention of stroke, myocardial infarction, and related vascular death in patients with vascular disease. Intracranial hemorrhage related with using antithrombotic agents, including clopidogrel can occur. We report a case of a 68-year-old-man who developed intracranial bleeding following clopidogrel usage that, until now such a complication has not been yet reported.

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References

  1. Meyers KM, Holmsen H, Seachord CL. Comparative study of platelet dense granule constituents. Am J Physiol 1982;243:R454–R461.

    Google Scholar 

  2. Gardner A, Jonsen J, Laland S, Hellem A, Owren P. Adenosine diphosphate in red blood cells as a factor in the adhesiveness of human blood platelets. Nature 1961;192:531–532.

    Google Scholar 

  3. Nacul FE, de Moraes E, Penido C, Paiva RB, Meier-Neto JG. Massive nasal bleeding and hemodynamic instability associated with clopidogrel. Pharm World Sci 2004;26(1):6–7.

    Google Scholar 

  4. Kilaru PK, Schweiger MJ, Kozman HA, Weil TR. Diffuse alveolar hemorrhage after clopidogrel use. J Invasive Cardiol 2001;13(7):535–537.

    Google Scholar 

  5. Gill DS, Ng K, Ng KS. Massive pulmonary hemorrhage complicating the treatment of acute coronary syndrome. Heart 2004;90(3):e15.

    Google Scholar 

  6. Gille J, Bernotat J, Bohm S, Behrens P, Lohr JF. Spontaneous hemarthrosis of the knee associated with clopidogrel and aspirin treatment. Z Rheumatol 2003;62(1):80–81.

    Google Scholar 

  7. Ng FH, Wong SY, Chang CM, et al. High incidence of clopidogrel-associated gastrointestinal bleeding in patients with previous peptic ulcer disease. Aliment Pharmacol Ther 2003;18(4):443–449.

    Google Scholar 

  8. Bittle JA. Advances in coronary angioplasty. N Engl J Med 1996;335:1290–1302.

    Google Scholar 

  9. Serruys PW, van Hout B, Bonnier H, et al. for the Benestent Study Group. Randomized comparison of implantation of heparin-coated stents with balloon angioplasty in selected patients with coronary artery disease (Benestent II). Lancet 1998;352:673–681.

    Google Scholar 

  10. Lincoff AM, Califf RM, Moliterno DJ, et al. for the Evaluation of Platelet IIb/IIIa Inhibition in Stenting Investigators. Complementary clinical benefits of coronary artery stenting and blockade of platelet glycoprotein IIb/IIIa receptors. N Engl J Med 1999;341:319–327.

    Google Scholar 

  11. Angiolillo DJ, Fernandez-Ortiz A, Bernardo E, et al. High clopidogrel loading dose during coronary stenting: effects on drug response and interindividual variability. Eur Heart J 2004 Nov;25(21):1903–1910.

    Google Scholar 

  12. The CAPRIE Steering Committee. A randomized, blinded, trial of clopidogrel versus aspirin in patients at risk of ischemic events. Lancet 1996;348:1329–1339.

    Google Scholar 

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Correspondence to Serkan Cay.

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Cay, S., Yilmaz, M.B. & Korkmaz, S. Intracranial Bleeding Associated with Clopidogrel. Cardiovasc Drugs Ther 19, 157–158 (2005). https://doi.org/10.1007/s10557-005-0896-y

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  • DOI: https://doi.org/10.1007/s10557-005-0896-y

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