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Targeting microRNAs as a promising anti-cancer therapeutic strategy against traffic-related air pollution-mediated lung cancer

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Abstract

Air pollutants are increasingly emitted into the atmosphere because of the high dependency of humans on fossil-derived fuels. Wind speed and direction assisted high dispersibility and uncontrolled nature of air pollution across geo-/demographical borders, making it one of the major global concerns. Besides climate change, air pollution has been found to be associated with various diseases, such as cancer. Lung cancer, which is the world’s most common type of cancer, has been found to be associated with traffic-related air pollution. Research and political efforts have been taken to explore green/renewable energy sources. However, these efforts at the current intensity cannot cope with the increasing need for fossil fuels. More specifically, political tensions such as the Russian-Ukraine war, economic tension (e.g., China-USA economic tensions), and other issues (e.g., pandemic, higher inflation rate, and poverty) significantly hindered phasing out fossil fuels. In this context, an increasing global population will be exposed to traffic-related air pollution, which justifies the current uptrend in the number of lung cancer patients. To combat this health burden, novel treatments with higher efficiency and specificity must be designed. One of the potential “life changer” options is microRNA (miRNA)-based therapy to target the expression of oncogenic genes. That said, this review discusses the association of traffic-related air pollution with lung cancer, the changes in indigenous miRNAs in the body during lung cancer, and the current status of miRNA therapeutics for lung cancer treatment. We believe that the article will significantly appeal to a broad readership of oncologists, environmentalists, and those who work in the field of (bio)energy. It may also gain the policymakers’ attention to establish better health policies and regulations about air pollution, for example, by promoting (bio)fuel exploration, production, and consumption.

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Funding

The authors would like to thank Universiti Malaysia Terengganu under International Partnership Research Grant (UMT/CRIM/2-2/2/23 (23), Vot 55302) for supporting this joint project with Henan Agricultural University under a Research Collaboration Agreement (RCA). This work is also supported by the Ministry of Higher Education, Malaysia, under the Higher Institution Centre of Excellence (HICoE), Institute of Tropical Aquaculture and Fisheries (AKUATROP) program (Vot. No. 56052, UMT/CRIM/2-2/5 Jilid 2 (11)). The manuscript is also supported by the Program for Innovative Research Team (in Science and Technology) at the University of Henan Province (No. 21IRTSTHN020) and the Central Plain Scholar Funding Project of Henan Province (No. 212101510005). The authors would also like to extend their sincere appreciation to the University of Tehran and the Biofuel Research Team (BRTeam) for their support throughout this project.

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Authors and Affiliations

  1. Henan Province Engineering Research Center for Biomass Value-Added Products, School of Forestry, Henan Agricultural University, Zhengzhou, 450002, China

    Hamed Kazemi Shariat Panahi, Wanxi Peng & Meisam Tabatabaei

  2. Neuroinflammation Group, Department of Biomedical Sciences, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia

    Hamed Kazemi Shariat Panahi & Mona Dehhaghi

  3. Biofuel Research Team (BRTeam), Kuala Terengganu, Terengganu, Malaysia

    Hamed Kazemi Shariat Panahi & Mona Dehhaghi

  4. Department of Mechanical Engineering of Agricultural Machinery, Faculty of Agricultural Engineering and Technology, College of Agriculture and Natural Resources, University of Tehran, Karaj, Iran

    Mortaza Aghbashlo

  5. Higher Institution Centre of Excellence (HICoE), Institute of Tropical Aquaculture and Fisheries (AKUATROP), Universiti Malaysia Terengganu, 21030, Kuala Nerus, Terengganu, Malaysia

    Meisam Tabatabaei

  6. Department of Biomaterials, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Chennai, 600 077, India

    Meisam Tabatabaei

  7. ICTRYM Pty Ltd, Sydney, Australia

    Gilles J. Guillemin

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  1. Hamed Kazemi Shariat Panahi
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  2. Mona Dehhaghi
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  3. Gilles J. Guillemin
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  4. Wanxi Peng
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  5. Mortaza Aghbashlo
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Contributions

H.K.S.P and M.D. wrote the original draft of the manuscript; G.J.G. contributed to some of the resources needed for the execution of the project; W.P., M.A., and M.T. conceptualized the idea of the manuscript, provided the required resources, and supervised the whole process. All authors reviewed the manuscript.

Corresponding authors

Correspondence to Wanxi Peng, Mortaza Aghbashlo or Meisam Tabatabaei.

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Kazemi Shariat Panahi, H., Dehhaghi, M., Guillemin, G.J. et al. Targeting microRNAs as a promising anti-cancer therapeutic strategy against traffic-related air pollution-mediated lung cancer. Cancer Metastasis Rev (2023). https://doi.org/10.1007/s10555-023-10142-x

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