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Nutraceutical use in late-stage cancer

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Abstract

Access to a wealth of information on the internet has led many cancer patients to use complementary methods as an adjunct to traditional therapy for cancer, with, and more often, without informing their primary caregiver. Of the common complementary modalities, the use of dietary supplements appears to be highly prevalent in patients in active treatment for cancer, and later in cancer survivors. Emerging research suggests that some plant-based agents may, indeed, impact late-stage cancer, influencing molecular processes corrupted by tumor cells to evade detection, expand clonally, and invade surrounding tissues. The intent of this article is to review some of the current science underpinning the use of nutraceuticals in the latter stages of cancer.

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Abbreviations

CAM:

Complementary and alternative medicine

COX:

Cycloxygenase

DNMT:

DNA methyltransferase

EGFR:

Epidermal growth factor receptor

ER:

Estrogen receptor

IGF:

Insulin-like growth factor

LOX:

Lipoxygenase

MCP:

Monocyte chemoattractant protein

MMP:

Matrix metalloproteinase

RECK:

The reversion-inducing cysteine-rich protein with Kazal motifs

TIMP:

Matrix metalloproteinase tissue inhibitor

VEGF:

Vascular endothelial growth factor

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Acknowledgments

This publication was supported in part by grant R01CA96694 from the National Cancer Institute.

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Authors and Affiliations

  1. Department of Cell & Molecular Pharmacology and Experimental Therapeutics, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, 29245, USA

    Michael J. Wargovich, Jay Morris, Vondina Brown & Rebecca Weber

  2. Department of Biology, Presbyterian College, Clinton, SC, 29325, USA

    Jane Ellis

  3. Department of Chemistry, University of South Carolina, Columbia, SC, 29225, USA

    Britt Logothetis

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  1. Michael J. Wargovich
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Correspondence to Michael J. Wargovich.

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Wargovich, M.J., Morris, J., Brown, V. et al. Nutraceutical use in late-stage cancer. Cancer Metastasis Rev 29, 503–510 (2010). https://doi.org/10.1007/s10555-010-9240-5

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