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Improvement of continuous subcutaneous insulin infusion on patients with type 2 diabetes mellitus by 3-dimensional speckle tracking echocardiography

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Abstract

Three-dimensional speckle tracking echocardiography (3D-STE) was used to evaluate the improvement of continuous subcutaneous insulin infusion on the left ventricular (LV) systolic function of patients with type 2 diabetes mellitu (T2DM). We recruited T2DM patients (38 cases, diabetic group) and healthy volunteers (35 cases, control group) to collect LV full volume imaging. TomTec software was used for calculating LV global longitudinal strain (LVGLS), global circumferential strain (LVGCS), peak twist (LVTW), peak apical rotation (LVPAR), ejection fraction (LVEF), and torsion (LVT). All indices were re-tested 2 weeks later after intensive treatment of insulin pump. LVGLS, LVGCS, LVTW and LVPAR in diabetic group were significantly decreased than control group. LVGLS and LVGCS in pre-treatment diabetic group were significantly increased than post-treatment. LVGLS, LVGCS, LVTW and LVPAR had correlations among control, pre-treatment and post-treatment diabetic groups. There were no significant differences in LVEDV, LVESV, LVEF, LVT and R-R. LV systolic function of patients with T2DM complicated with microangiopathy was improved after treatment of continuous subcutaneous insulin infusion. In addition, therapeutic effect could be accurately evaluated by 3D-STE which had vital clinical application.

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Author notes

  1. Hong-xia Luo and Xiao-ling Zhou have contributed equally to this work.

Authors and Affiliations

  1. Department of Ultrasonic Diagnosis, The Second Affiliated Hospital and Yuying Children’s Hospital, Wenzhou Medical University, No.109 Xueyuan West Road, Lucheng District, Wenzhou, 325000, Zhejiang, China

    Hong-xia Luo, Hong-ju Kou, Xian-wei Ni, Qing Wu, Chun-peng Zou, Dao-zhu Wu & Yong-fang Liu

  2. Department of Medical Ultrasound, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China

    Xiao-ling Zhou

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  1. Hong-xia Luo
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Correspondence to Dao-zhu Wu or Yong-fang Liu.

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Luo, Hx., Zhou, Xl., Kou, Hj. et al. Improvement of continuous subcutaneous insulin infusion on patients with type 2 diabetes mellitus by 3-dimensional speckle tracking echocardiography. Int J Cardiovasc Imaging 34, 379–384 (2018). https://doi.org/10.1007/s10554-017-1245-5

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  • DOI: https://doi.org/10.1007/s10554-017-1245-5

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