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Intravascular ultrasound and optical coherence tomography imaging of coronary atherosclerosis

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Abstract

Invasive imaging modalities, in particular intravascular ultrasound (IVUS) and optical coherence tomography (OCT), have become established tools for the in vivo study of coronary atherosclerosis. Their use in clinical studies has confirmed histopathological observations that certain important plaque features, such as thin fibrous caps and large lipid cores, are associated with plaque rupture, the precipitating event for the majority of myocardial infarctions. Serial imaging studies have also successfully been used for the evaluation of potential disease modifying pharmacological agents. Recent prospective IVUS studies have confirmed specific baseline imaging features associated with subsequent adverse clinical outcomes, although absolute event rates were too low for clinical utility. Development of hybrid IVUS–OCT imaging or integration of novel techniques, including near-infrared spectroscopy, plaque structural and endothelial shear stress, have great potential to improve our current ability to identify and stratify atheromatous plaques at risk of rupture.

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Acknowledgments

This study was supported by British Heart Foundation grants FS/13/33/30168, RG/13/14/30314, Heart Research UK grant RG2638/14/16 and the NIHR Cambridge Biomedical Research Centre.

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    Authors and Affiliations

    1. Division of Cardiovascular Medicine, University of Cambridge, Level 6, ACCI, Addenbrooke’s Hospital, Cambridge, CB2 0QQ, UK

      Charis Costopoulos, Adam J. Brown & Martin R. Bennett

    2. Department of Interventional Cardiology, Papworth Hospital NHS Trust, Cambridge, UK

      Adam J. Brown, Stephen P. Hoole & Nick E. J. West

    3. Department of Radiology, University of Cambridge, Cambridge, UK

      Zhongzhao Teng

    4. Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA

      Habib Samady

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    1. Charis Costopoulos
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    2. Adam J. Brown
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    Correspondence to Adam J. Brown.

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    Charis Costopoulos and Adam J. Brown have contributed equally to this work.

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    Costopoulos, C., Brown, A.J., Teng, Z. et al. Intravascular ultrasound and optical coherence tomography imaging of coronary atherosclerosis. Int J Cardiovasc Imaging 32, 189–200 (2016). https://doi.org/10.1007/s10554-015-0701-3

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    • DOI: https://doi.org/10.1007/s10554-015-0701-3

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