Abstract
Purpose
Renal cell carcinoma (RCC) incidence is higher among black than white Americans. The reasons for this disparity remain unclear.
Methods
We calculated race- and sex-specific population attributable risk percentages (PAR%) and their 95% confidence intervals (CI) for hypertension and chronic kidney disease (CKD) among black and white subjects ≥ 50 years of age from the US Kidney Cancer Study (USKC; 965 cases, 953 controls), a case–control study in Chicago and Detroit, and a nested case–control study in the Kaiser Permanente Northern California health care network (KPNC; 2,162 cases, 21,484 controls). We also estimated PAR% for other modifiable RCC risk factors (cigarette smoking, obesity) in USKC.
Results
In USKC, the PAR% for hypertension was 50% (95% CI 24–77%) and 44% (95% CI 25–64%) among black women and men, respectively, and 29% (95% CI 13–44%) and 27% (95% CI 14–39%) for white women and men, respectively. In KPNC, the hypertension PAR% was 40% (95% CI 18–62%) and 23% (95% CI 2–44%) among black women and men, and 27% (95% CI 20–35%) and 19% (95% CI 14–24%) among white women and men, respectively. The PAR% for CKD in both studies ranged from 7 to 10% for black women and men but was negligible (<1%) for white subjects. In USKC, the PAR% for current smoking was 20% and 8% among black and white men, respectively, and negligible and 8.6% for black and white women, respectively. The obesity PAR% ranged from 12 to 24% across all race/sex strata.
Conclusions
If the associations found are causal, interventions that prevent hypertension and CKD among black Americans could potentially eliminate the racial disparity in RCC incidence (hypothetical black:white RCC incidence ratio of 0.5).
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References
National Cancer Institute. SEER*Explorer. https://seer.cancer.gov/explorer/application.php?site=630&data_type=1&graph_type=2&compareBy=race&chk_sex_1=1&chk_sex_2=2&chk_race_3=3&chk_race_2=2&chk_age_range_1=1&hdn_data_type=1&advopt_precision=1&advopt_display=2&showDataFor=sex_2_and_age_range_1
Chow WH, Shuch B, Linehan WM et al (2013) Racial disparity in renal cell carcinoma patient survival according to demographic and clinical characteristics. Cancer 119(2):388–394. https://doi.org/10.1002/cncr.27690
Cutler JA, Sorlie PD, Wolz M et al (2008) Trends in hypertension prevalence, awareness, treatment, and control rates in United States adults between 1988–1994 and 1999–2004. Hypertension 52(5):818–827. https://doi.org/10.1161/HYPERTENSIONAHA.108.113357
Centers for Disease Control and Prevention (CDC) (2007) Prevalence of chronic kidney disease and associated risk factors—United States, 1999–2004. MMWR Morb Mortal Wkly Rep 56(8):161–165
Ogden CL, Carroll MD, Curtin LR et al (2006) Prevalence of overweight and obesity in the United States, 1999–2004. JAMA 295(13):1549–1555. https://doi.org/10.1001/jama.295.13.1549
Hofmann JN, Schwartz K, Chow WH et al (2013) The association between chronic renal failure and renal cell carcinoma may differ between black and white Americans. Cancer Causes Control 24(1):167–174. https://doi.org/10.1007/s10552-012-0102-z
Colt JS, Schwartz K, Graubard BI et al (2011) Hypertension and risk of renal cell carcinoma among White and Black Americans. Epidemiology 22(6):797–804. https://doi.org/10.1097/EDE.0b013e3182300720
Hall EC, Segev DL, Engels EA (2013) Racial/ethnic differences in cancer risk after kidney transplantation. Am J Transpl 13(3):714–720. https://doi.org/10.1111/ajt.12066
Hofmann JN, Corley DA, Zhao WK et al (2015) Chronic kidney disease and risk of renal cell carcinoma: differences by race. Epidemiology 26(1):59–67. https://doi.org/10.1097/EDE.0000000000000205
Beebe-Dimmer JL, Colt JS, Ruterbusch JJ et al (2012) Body mass index and renal cell cancer: the influence of race and sex. Epidemiology (Cambridge, Mass) 23(6):821–828. https://doi.org/10.1097/EDE.0b013e31826b7fe9
Gago-Dominguez M, Castelao JE (2006) Lipid peroxidation and renal cell carcinoma: further supportive evidence and new mechanistic insights. Free Radic Biol Med 40(4):721–733. https://doi.org/10.1016/j.freeradbiomed.2005.09.026
Bruzzi P, Green SB, Byar DP et al (1985) Estimating the population attributable risk for multiple risk factors using case–control data. Am J Epidemiol 122(5):904–914
Benichou J, Gail MH (1990) Variance calculations and confidence intervals for estimates of the attributable risk based on logistic models. Biometrics 46(4):991–1003
Graubard BI, Fears TR (2005) Standard errors for attributable risk for simple and complex sample designs. Biometrics 61(3):847–855. https://doi.org/10.1111/j.1541-0420.2005.00355.x
Surveillance E, End Results (SEER) Program (www.seer.cancer.gov). Research data. In: National Cancer Institute D, Surveillance Research Program, ed. based on the November 2016 submission ed, 1973–2014
Setiawan VW, Stram DO, Nomura AM et al (2007) Risk factors for renal cell cancer: the multiethnic cohort. Am J Epidemiol 166(8):932–940. https://doi.org/10.1093/aje/kwm170
Benichou J, Chow WH, McLaughlin JK et al (1998) Population attributable risk of renal cell cancer in Minnesota. Am J Epidemiol 148(5):424–430
Callahan CL, Hofmann JN, Corley DA et al (2018) Obesity and renal cell carcinoma risk by histologic subtype: a nested case–control study and meta-analysis. Cancer Epidemiol 56:31–37. https://doi.org/10.1016/j.canep.2018.07.002
Purdue MP, Moore LE, Merino MJ et al (2013) An investigation of risk factors for renal cell carcinoma by histologic subtype in two case–control studies. Int J Cancer 132(11):2640–2647. https://doi.org/10.1002/ijc.27934
Cheng S, Claggett B, Correia AW et al (2014) Temporal trends in the population attributable risk for cardiovascular disease: the Atherosclerosis Risk in Communities Study. Circulation 130(10):820–828. https://doi.org/10.1161/circulationaha.113.008506
Acknowledgments
This work was supported by the Intramural Research Program of the US National Cancer Institute (NCI), National Institutes of Health (NIH).
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Callahan, C.L., Schwartz, K., Corley, D.A. et al. Understanding racial disparities in renal cell carcinoma incidence: estimates of population attributable risk in two US populations. Cancer Causes Control 31, 85–93 (2020). https://doi.org/10.1007/s10552-019-01248-1
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DOI: https://doi.org/10.1007/s10552-019-01248-1