Abstract
Hypothalamic hamartomas (HH) are typically associated with gelastic seizures but also implicated in the genesis of other seizure types. In order to identify networks involved in seizure generation, we performed EEG-fMRI in two adult patients with HH, the first with predominantly gelastic seizures and the second with complex partial and no typical gelastic seizures. The ictal and interictal analysis of the patient with gelastic seizures revealed the involvement of the HH, the cingulate gyrus, the precuneus and the prefrontal cortex. The interictal analysis of the patient with complex partial seizures, showed changes in blood oxygen-level dependent signal over the temporal lobes, the base of the frontal lobe, the cingulate, the precuneus and the prefrontal cortex, but not the HH. The differences in the neural networks implicated may account for differences in clinical manifestation of seizures owing to HH.
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Acknowledgments
The authors acknowledge the contribution of Neuropathologist Ingmar Blümcke of the University of Erlagen, Neurologist Jean Harushukuri, the radiology technicians of “St.Luke’s” Hospital: Konstantinos Anthis, Michalis Bakaloudis, Georgios Chatzisfetkos, and Christos Zacharias, and Thalia Kalatha of the neurosurgical team. We thank Dr. Helmut Laufs of the University of the Johann Wolfgang Goethe University for licensing the use of his MatLab scripts for EEG-fMRI analysis.
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Kokkinos, V., Zountsas, B., Kontogiannis, K. et al. Epileptogenic Networks in Two Patients with Hypothalamic Hamartoma. Brain Topogr 25, 327–331 (2012). https://doi.org/10.1007/s10548-011-0214-x
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DOI: https://doi.org/10.1007/s10548-011-0214-x