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Toxicity and preventive approaches of Fusarium derived mycotoxins using lactic acid bacteria: state of the art

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Abstract

Mycotoxin contamination of food and feed is a serious food safety issue and causes acute and chronic diseases in humans and livestock. Climatic and agronomic changes helps in the proliferation of fungal growth and mycotoxin production in food commodities. Mycotoxin contamination has attracted global attention due to its wide range of toxicity to humans and animals. However, physical and chemical management approaches in practice are unsafe for well-being due to their health-hazardous nature. Various antibiotics and preservatives are in use to reduce the microbial load and improve the shelf life of food products. In addition, the use of antibiotic growth promotors in livestock production may increase the risk of antimicrobial resistance, which is a global health concern. Due to their many uses, probiotics are helpful microbes that have a significant impact on food and nutrition. Furthermore, the probiotic potential of lactic acid bacteria (LAB) is employed in various food and feed preparations to neutralize mycotoxins, antimicrobial activities, balance the gut microbiome, and various immunomodulatory activities in both humans and livestock. In addition, LAB produces various antimicrobials, flavouring agents, peptides, and proteins linked to various food and health care applications. The LAB-based processes for mycotoxin management are more effective, eco-friendly, and low-cost than physical and chemical approaches. The toxicity, novel preventive measures, binding nature, and molecular mechanisms of mycotoxins' detoxification using LAB have been highlighted in this review.

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Acknowledgements

This work was supported by Science and Engineering Research Board (SERB), Department of Science and Technology, India (EEQ/2017/000502), Department of Biotechnology (DBT), Ministry of Science and Technology, India (BT/PR27494/NNT/28/1549/2018) and CSIR-National Chemical Laboratory for the necessary facilities.

Funding

Funding was provided by Science and Engineering Research Board (Grant No. EEQ/2017/000502), Department of Biotechnology,Ministry of Science and Technology (Grant No. BT/PR27494/NNT/28/1549/2018)

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  1. Biochemical Sciences Division, CSIR-National Chemical Laboratory, Pune, 411008, India

    Vishwambar D. Navale & KoteswaraRao Vamkudoth

  2. Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, New Delhi, India

    Vishwambar D. Navale & KoteswaraRao Vamkudoth

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  1. Vishwambar D. Navale
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  2. KoteswaraRao Vamkudoth
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Correspondence to KoteswaraRao Vamkudoth.

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Navale, V.D., Vamkudoth, K. Toxicity and preventive approaches of Fusarium derived mycotoxins using lactic acid bacteria: state of the art. Biotechnol Lett 44, 1111–1126 (2022). https://doi.org/10.1007/s10529-022-03293-4

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