Skip to main content

Advertisement

SpringerLink
Log in

Biosensors, modern technology for the detection of cancer-associated bacteria

  • Review
  • Published:
Biotechnology Letters Aims and scope Submit manuscript

Abstract

Cancer is undoubtedly one of the major human challenges worldwide. A number of pathogenic bacteria are deemed to be potentially associated with the disease. Accordingly, accurate and specific identification of cancer-associated bacteria can play an important role in cancer control and prevention. A variety of conventional methods such as culture, serology, and molecular-based methods as well as PCR and real-time PCR have been adopted to identify bacteria. However, supply costs, machinery fees, training expenses, consuming time, and the need for advanced equipment are the main problems with the old methods. As a result, advanced and modern techniques are being developed to overcome the disadvantages of conventional methods. Biosensor technology is one of the innovative methods that has been the focus of researchers due to its numerous advantages. The main purpose of this study is to provide an overview of the latest developed biosensors for recognizing the paramount cancer-associated bacteria.

Graphical abstract

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

Reproduced from Ref. (Duan et al. 2016a)

Fig. 3

Reproduced from Ref. (Sheikhzadeh et al. 2016)

Fig. 4

Reproduced from Ref. (Yuan et al. 2014)

Fig. 5

Reproduced from Ref. (Duan et al. 2016b)

Fig. 6

Reproduced from Ref. (Salam and Tothill 2009)

Fig. 7

Reproduced from Ref. (Li et al. 2010)

Fig. 8

Reproduced from Ref. (Hossein-Nejad-Ariani et al. 2018)

Fig. 9

Reproduced from Ref. (Niu et al. 2017)

Fig. 10

Reproduced from Ref. (Liu et al. 2017)

Fig. 11

Reproduced from Ref. (Liu et al. 2016)

Fig. 12
Fig. 13
Fig. 14

Reproduced from Ref. (Chen et al. 2018b)

Fig. 15

Similar content being viewed by others

References

  • Al-Hilu SA, Al-Shujairi WH (2020) Dual role of bacteria in carcinoma: stimulation and inhibition. Int J Microbiol 2020:1–15

    Article  CAS  Google Scholar 

  • Ashrafi H, Mobed A, Hasanzadeh M, Babaie P, Ansarin K, Jouyban A (2019) Monitoring of five benzodiazepines using a novel polymeric interface prepared by layer by layer strategy. Microchem J 146:121–125

    Article  CAS  Google Scholar 

  • Bonner MJ (2017) Review of current methods used in bacteriology. Methods of detection and identification of bacteria. CRC Press, Boca Raton, pp 13–82

    Google Scholar 

  • Brodowski M, Kowalski M, Skwarecka M, Pałka K, Skowicki M, Kula A, Lipiński T, Dettlaff A, Ficek M, Ryl J, Dziąbowska K, Nidzworski D, Bogdanowicz R (2021) Highly selective impedimetric determination of Haemophilus influenzae protein D using maze-like boron-doped carbon nanowall electrodes. Talanta 221:121623

    Article  CAS  PubMed  Google Scholar 

  • Çakar B, Çiledağ A (2018) Evaluation of coexistence of cancer and active tuberculosis; 16 case series. Respir Med Case Rep 23:33–37

    PubMed  Google Scholar 

  • Cassell GH, Cole BC (1981) Mycoplasmas as agents of human disease. N Engl J Med 304(2):80–89

    Article  CAS  PubMed  Google Scholar 

  • Caygill CP, Hill MJ, Braddick M, Sharp JC (1994) Cancer mortality in chronic typhoid and paratyphoid carriers. Lancet 343(8889):83–84

    Article  CAS  PubMed  Google Scholar 

  • Chaudhuri D, Roy Chowdhury A, Biswas B, Chakravortty D (2018) Salmonella typhimurium infection leads to colonization of the mouse brain and is not completely cured with antibiotics. Front Microbiol. https://doi.org/10.3389/fmicb.2018.01632

    Article  PubMed  PubMed Central  Google Scholar 

  • Chen Q, Huang F, Cai G, Wang M, Lin J (2018a) An optical biosensor using immunomagnetic separation, urease catalysis and pH indication for rapid and sensitive detection of Listeria monocytogenes. Sens Actuators B Chem 258:447–453

    Article  CAS  Google Scholar 

  • Chen L-L, Cui H-F, Fan S-F, Li Z-Y, Han S-Y, Ma X, Luo S-W, Song X, Lv Q-Y (2018b) Detection of Helicobacter pylori in dental plaque using a DNA biosensor for noninvasive diagnosis. RSC Adv 8(38):21075–21083

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cheung KS, Chan EW, Wong AY, Chen L, Wong IC, Leung WK (2018) Long-term proton pump inhibitors and risk of gastric cancer development after treatment for Helicobacter pylori: a population-based study. Gut 67(1):28–35

    Article  CAS  PubMed  Google Scholar 

  • Chumduri C, Gurumurthy RK, Zietlow R, Meyer TF (2016) Subversion of host genome integrity by bacterial pathogens. Nat Rev Mol Cell Biol 17(10):659–673

    Article  CAS  PubMed  Google Scholar 

  • Cohen HJ, Mechanda SM, Lin W (1996) PCR amplification of the fimA gene sequence of Salmonella typhimurium, a specific method for detection of Salmonella spp. Appl Environ Microbiol 62(12):4303–4308

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Crosby DA, Crankshaw DJ, Morrison JJ (2016) 202: Human myometrial in vitro effects of pharmacological agents used in the clinical management of postpartum hemorrhage. Am J Obstetrics Gynecol 214(1):S122–S123

  • Damborský P, Švitel J, Katrlík J (2016) Optical biosensors. Essays Biochem 60(1):91–100

    Article  PubMed  PubMed Central  Google Scholar 

  • Davis D, Guo X, Musavi L, Lin CS, Chen SH, Wu VC (2013) Gold nanoparticle-modified carbon electrode biosensor for the detection of Listeria monocytogenes. Ind Biotechnol 9(1):31–36

    Article  CAS  Google Scholar 

  • Demirel G, Usta H, Yilmaz M, Celik M, Alidagi HA, Buyukserin F (2018) Surface-enhanced Raman spectroscopy (SERS): an adventure from plasmonic metals to organic semiconductors as SERS platforms. J Mater Chem C 6(20):5314–5335

    Article  CAS  Google Scholar 

  • Duan N, Chang B, Zhang H, Wang Z, Wu S (2016a) Salmonella typhimurium detection using a surface-enhanced Raman scattering-based aptasensor. Int J Food Microbiol 218:38–43

    Article  CAS  PubMed  Google Scholar 

  • Duan N, Xu B, Wu S, Wang Z (2016b) Magnetic nanoparticles-based aptasensor using gold nanoparticles as colorimetric probes for the detection of Salmonella typhimurium. Anal Sci 32(4):431–436

    Article  CAS  PubMed  Google Scholar 

  • Eissa S, Zourob M (2020) Ultrasensitive peptide-based multiplexed electrochemical biosensor for the simultaneous detection of Listeria monocytogenes and Staphylococcus aureus. Microchim Acta 187(9):486

    Article  CAS  Google Scholar 

  • Gabaldón T (2019) Recent trends in molecular diagnostics of yeast infections: from PCR to NGS. FEMS Microbiol Rev 43(5):517–547

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Gupta S, Jain U, Murti BT, Putri AD, Tiwari A, Chauhan N (2020) Nanohybrid-based immunosensor prepared for Helicobacter pylori BabA antigen detection through immobilized antibody assembly with @ Pdnano/rGO/PEDOT sensing platform. Sci Rep 10(1):21217

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hadjilouka A, Loizou K, Apostolou T, Dougiakis L, Inglezakis A, Tsaltas D (2020) Newly developed system for the robust detection of Listeria monocytogenes based on a bioelectric cell biosensor. Biosensors 10(11):178

    Article  CAS  PubMed Central  Google Scholar 

  • Hassan R, Alley E, Kindler H, Antonia S, Jahan T, Honarmand S, Nair N, Whiting CC, Enstrom A, Lemmens E (2019) Clinical response of live-attenuated, listeria monocytogenes expressing mesothelin (CRS-207) with chemotherapy in patients with malignant pleural mesothelioma. Clin Cancer Res 25(19):5787–5798

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hazan R, Que Y-A, Maura D, Rahme LG (2012) A method for high throughput determination of viable bacteria cell counts in 96-well plates. BMC Microbiol 12:259–259

    Article  PubMed  PubMed Central  Google Scholar 

  • Heimann DM, Rosenberg SA (2003) Continuous intravenous administration of live genetically modified Salmonella typhimurium in patients with metastatic melanoma. J Immunother 26(2):179–180

    Article  PubMed  PubMed Central  Google Scholar 

  • Hossein-Nejad-Ariani H, Kim T, Kaur K (2018) Peptide-based biosensor utilizing fluorescent gold nanoclusters for detection of Listeria monocytogenes. ACS Appl Nano Mater 1(7):3389–3397

    Article  CAS  Google Scholar 

  • Huang Y, Xu T, Wang W, Wen Y, Li K, Qian L, Zhang X, Liu G (2019) Lateral flow biosensors based on the use of micro- and nanomaterials: a review on recent developments. Microchim Acta 187(1):70

    Article  CAS  Google Scholar 

  • Johnson I, Williamson G, Musk SRR (1994) Anticarcinogenic factors in plant foods: a new class of nutrients? Nutr Res Rev 7(1):175–204

    Article  CAS  PubMed  Google Scholar 

  • Kaewphinit T, Santiwatanakul S, Jaratsing P, Chansiri K, Arunrut N, Kiatpathomchai W (2012) Detection of Mycobacterium tuberculosis by using loop-mediated isothermal amplification combined with a lateral flow dipstick biosensor. The 4th 2011 biomedical engineering international conference. IEEE, Chiang Mai, pp 86–88

    Chapter  Google Scholar 

  • Kaltenboeck B, Wang C (2005) Advances in real-time PCR: application to clinical laboratory diagnostics. Adv Clin Chem 40:219

    Article  CAS  PubMed  Google Scholar 

  • Khan AA, Shrivastava A (2010) Bacterial infections associated with cancer: possible implication in etiology with special reference to lateral gene transfer. Cancer Metastasis Rev 29(2):331–337

    Article  PubMed  Google Scholar 

  • Lakshmanan RS, Guntupalli R, Hu J, Petrenko VA, Barbaree JM, Chin BA (2007) Detection of Salmonella typhimurium in fat free milk using a phage immobilized magnetoelastic sensor. Sens Actuators B Chem 126(2):544–550

    Article  CAS  Google Scholar 

  • Li S, Li Y, Chen H, Horikawa S, Shen W, Simonian A, Chin BA (2010) Direct detection of Salmonella typhimurium on fresh produce using phage-based magnetoelastic biosensors. Biosens Bioelectron 26(4):1313–1319

    Article  CAS  PubMed  Google Scholar 

  • Li X, Chen N, Zhou X, Gong P, Wang S, Zhang Y, Zhao Y (2021) A review of specialty fiber biosensors based on interferometer configuration. J Biophotonics 14(6):e202100068

    CAS  PubMed  Google Scholar 

  • Liu L, Xiang G, Jiang D, Du C, Liu C, Huang W, Pu X (2016) Electrochemical gene sensor for Mycoplasma pneumoniae DNA using dual signal amplification via a Pt@ Pd nanowire and horse radish peroxidase. Microchim Acta 183(1):379–387

    Article  CAS  Google Scholar 

  • Liu H-B, Du X-J, Zang Y-X, Li P, Wang S (2017) SERS-based lateral flow strip biosensor for simultaneous detection of Listeria monocytogenes and Salmonella enterica serotype Enteritidis. J Agric Food Chem 65(47):10290–10299

    Article  CAS  PubMed  Google Scholar 

  • Loo VG, Richardson S, Quinn P (1991) Isolation of Mycoplasma pneumoniae from pleural fluid. Diagn Microbiol Infect Dis 14(5):443–445

    Article  CAS  PubMed  Google Scholar 

  • Lv M-M, Fan S-F, Wang Q-L, Lv Q-Y, Song X, Cui H-F (2019) An enzyme-free electrochemical sandwich DNA assay based on the use of hybridization chain reaction and gold nanoparticles: application to the determination of the DNA of Helicobacter pylori. Microchim Acta 187(1):73

    Article  CAS  Google Scholar 

  • Mahmoudpour M, Dolatabadi JEN, Torbati M, Tazehkand AP, Homayouni-Rad A, de la Guardia M (2019) Nanomaterials and new biorecognition molecules based surface plasmon resonance biosensors for mycotoxin detection. Biosens Bioelectron 143:111603

    Article  CAS  PubMed  Google Scholar 

  • Malvano F, Pilloton R, Albanese D (2020) Label-free impedimetric biosensors for the control of food safety—a review. Int J Environ Anal Chem 100(4):468–491

    Article  CAS  Google Scholar 

  • Martins SAM, Martins VC, Cardoso FA, Germano JH, Rodrigues MC, Duarte CM, Bexiga R, De Freitas SC, de Freitas PP (2019) Biosensors for on-farm diagnosis of mastitis. Front Bioeng Biotechnol 7:186

    Article  PubMed  PubMed Central  Google Scholar 

  • Mat Zaid MH, Abdullah J, Yusof NA, Sulaiman Y, Wasoh H, Md Noh MF, Issa R (2017) PNA biosensor based on reduced graphene oxide/water soluble quantum dots for the detection of Mycobacterium tuberculosis. Sens Actuators B Chem 241:1024–1034

    Article  CAS  Google Scholar 

  • Meza AD (n.d.) Typhoid fever: a rare occurrence in El Paso

  • Miller ND, Davidson P, D’Souza DH (2011) Real-time reverse-transcriptase PCR for Salmonella typhimurium detection from lettuce and tomatoes. LWT-Food Sci Technol 44(4):1088–1097

    Article  CAS  Google Scholar 

  • Miyake M, Ohnishi K, Hori S, Nakano A, Nakano R, Yano H, Ohnishi S, Owari T, Morizawa Y, Itami Y (2019) Mycoplasma genitalium infection and chronic inflammation in human prostate cancer: detection using prostatectomy and needle biopsy specimens. Cells 8(3):212

    Article  CAS  PubMed Central  Google Scholar 

  • Mobed A, Baradaran B, de la Guardia M, Agazadeh M, Hasanzadeh M, Rezaee MA, Mosafer J, Mokhtarzadeh A, Hamblin MR (2019a) Advances in detection of fastidious bacteria: from microscopic observation to molecular biosensors. TrAC Trends Anal Chem 113:157–171

    Article  CAS  Google Scholar 

  • Mobed A, Nami F, Hasanzadeh M, Hassanpour S, Saadati A, Mokhtarzadeh A (2019b) A novel nucleic acid based bio-assay toward recognition of Haemophilus influenza using bioconjugation and DNA hybridization method. Int J Biol Macromol 139:1239–1251

    Article  CAS  PubMed  Google Scholar 

  • Mobed A, Hasanzadeh M, Hassanpour S, Saadati A, Agazadeh M, Mokhtarzadeh A (2019c) An innovative nucleic acid based biosensor toward detection of Legionella pneumophila using DNA immobilization and hybridization: a novel genosensor. Microchem J 148:708–716

    Article  CAS  Google Scholar 

  • Mobed A, Hasanzadeh M, Shadjou N, Hassanpour S, Saadati A, Agazadeh M (2020a) Immobilization of ssDNA on the surface of silver nanoparticles-graphene quantum dots modified by gold nanoparticles towards biosensing of microorganism. Microchem J 152:104286

    Article  CAS  Google Scholar 

  • Mobed A, Shakouri SK, Dolati S (2020b) Biosensors: a novel approach to and recent discovery in detection of cytokines. Cytokine 136:155272

    Article  CAS  PubMed  Google Scholar 

  • Mobed A, Kohansal F, Ahmadalipour A, Hasanzadeh M, Zargari F (2020c) Bioconjugation of 2-arachidonic glycerol (2-AG) biotinylated antibody with gold nano-flowers toward immunoassay of 2-AG in human plasma samples: a novel immuno-platform for screening of immunomodulatory and neuroprotection. Anal Methods 13:311–321

    Article  Google Scholar 

  • Molina-Romero C, Arrieta O, Hernández-Pando R (2020) Tuberculosis and lung cancer. Salud Pública De México 61:286–291

    Article  Google Scholar 

  • Mondal B, Ramlal S, Lavu PS, Bhavanashri N, Kingston J (2018) Highly sensitive colorimetric biosensor for Staphylococcal enterotoxin B by a label-free aptamer and gold nanoparticles. Front Microbiol. https://doi.org/10.3389/fmicb.2018.00179

    Article  PubMed  PubMed Central  Google Scholar 

  • Mosele JI, Macià A, Motilva M-J (2015) Metabolic and microbial modulation of the large intestine ecosystem by non-absorbed diet phenolic compounds: a review. Molecules 20(9):17429–17468

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Moss SF (2017) The clinical evidence linking Helicobacter pylori to gastric cancer. Cell Mol Gastroenterol Hepatol 3(2):183–191

    Article  PubMed  Google Scholar 

  • Mughini-Gras L, Schaapveld M, Kramers J, Mooij S, Neefjes-Borst EA, Pelt WV, Neefjes J (2018) Increased colon cancer risk after severe Salmonella infection. PLoS ONE 13(1):e0189721–e0189721

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Mukundan H, Anderson AS, Grace WK, Grace KM, Hartman N, Martinez JS, Swanson BI (2009) Waveguide-based biosensors for pathogen detection. Sensors 9(7):5783–5809

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Niu X, Zheng W, Yin C, Weng W, Li G, Sun W, Men Y (2017) Electrochemical DNA biosensor based on gold nanoparticles and partially reduced graphene oxide modified electrode for the detection of Listeria monocytogenes hly gene sequence. J Electroanal Chem 806:116–122

    Article  CAS  Google Scholar 

  • Ohk SH, Koo OK, Sen T, Yamamoto CM, Bhunia AK (2010) Antibody–aptamer functionalized fibre-optic biosensor for specific detection of Listeria monocytogenes from food. J Appl Microbiol 109(3):808–817

    Article  CAS  PubMed  Google Scholar 

  • Ou F, McGoverin C, Swift S, Vanholsbeeck F (2019) Near real-time enumeration of live and dead bacteria using a fibre-based spectroscopic device. Sci Rep 9(1):4807

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Parsons LM, Somoskövi Á, Gutierrez C, Lee E, Paramasivan C, Abimiku AL, Spector S, Roscigno G, Nkengasong J (2011) Laboratory diagnosis of tuberculosis in resource-poor countries: challenges and opportunities. Clin Microbiol Rev 24(2):314–350

    Article  PubMed  PubMed Central  Google Scholar 

  • Peng P, Xu F, Xu Y, Sun S (2017) Fabrication of an electrochemical sensor for Helicobacter pylori in excrement based on a gold electrode. Int J Electrochem Sci 12(10):9478

    Article  CAS  Google Scholar 

  • Plekhanova YV, Reshetilov AN (2019) Microbial biosensors for the determination of pesticides. J Anal Chem 74(12):1159–1173

    Article  CAS  Google Scholar 

  • Prabowo BA, Chang Y-F, Lai H-C, Alom A, Pal P, Lee Y-Y, Chiu N-F, Hatanaka K, Su L-C, Liu K-C (2018) Rapid screening of Mycobacterium tuberculosis complex (MTBC) in clinical samples by a modular portable biosensor. Sens Actuators B Chem 254:742–748

    Article  CAS  Google Scholar 

  • Ren J, Liang G, Man Y, Li A, Jin X, Liu Q, Pan L (2019) Aptamer-based fluorometric determination of Salmonella typhimurium using Fe3O4 magnetic separation and CdTe quantum dots. PLoS ONE 14(6):e0218325–e0218325

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rivero GA, Torres HA, Rolston KVI, Kontoyiannis DP (2003) Listeria monocytogenes infection in patients with cancer. Diagn Microbiol Infect Dis 47(2):393–398

    Article  CAS  PubMed  Google Scholar 

  • Rogers MB (2011) Mycoplasma and cancer: in search of the link. Oncotarget 2(4):271–273

    Article  PubMed  PubMed Central  Google Scholar 

  • Russell W (1890) An address on a characteristic organism of cancer. Br Med J 2(1563):1356–1360

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Salam F, Tothill IE (2009) Detection of Salmonella typhimurium using an electrochemical immunosensor. Biosens Bioelectron 24(8):2630–2636

    Article  CAS  PubMed  Google Scholar 

  • Sheikhzadeh E, Chamsaz M, Turner APF, Jager EWH, Beni V (2016) Label-free impedimetric biosensor for Salmonella typhimurium detection based on poly [pyrrole-co-3-carboxyl-pyrrole] copolymer supported aptamer. Biosens Bioelectron 80:194–200

    Article  CAS  PubMed  Google Scholar 

  • Song M, Chan AT (2019) Hepatology, environmental factors, gut microbiota, and colorectal cancer prevention. Clin Gastroenterol Hepatol 17(2):275–289

    Article  CAS  PubMed  Google Scholar 

  • Song S, Wang L, Li J, Fan C, Zhao J (2008) Aptamer-based biosensors. TrAC Trends Anal Chem 27(2):108–117

    Article  CAS  Google Scholar 

  • Torati SR, Reddy V, Yoon SS, Kim C (2016) Electrochemical biosensor for Mycobacterium tuberculosis DNA detection based on gold nanotubes array electrode platform. Biosens Bioelectron 78:483–488

    Article  CAS  PubMed  Google Scholar 

  • Wang Y, Wang Y, Quan S, Jiao W, Li J, Sun L, Wang Y, Qi X, Wang X, Shen A (2019a) Establishment and application of a multiple cross displacement amplification coupled with nanoparticle-based lateral flow biosensor assay for detection of Mycoplasma pneumoniae. Front Cell Infect Microbiol. https://doi.org/10.3389/fcimb.2019.00325

    Article  PubMed  PubMed Central  Google Scholar 

  • Wang Y, Wang Y, Jiao W, Li J, Quan S, Sun L, Wang Y, Qi X, Wang X, Shen A (2019b) Development of loop-mediated isothermal amplification coupled with nanoparticle-based lateral flow biosensor assay for Mycoplasma pneumoniae detection. AMB Express 9(1):196

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Watson SC (2019) Investigation of the bacterial safety of fermented and dried duck salami

  • Wen X, Wen D, Yang Y, Chen Y, Wang G, Shan B (2017) Urban-rural disparity in Helicobacter pylori infection-related upper gastrointestinal cancer in China and the decreasing trend in parallel with socioeconomic development and urbanization in an endemic area. Ann Global Health 83(3–4):444–462

    Article  Google Scholar 

  • Yao J, Yang M, Duan Y (2014) Chemistry, biology, and medicine of fluorescent nanomaterials and related systems: new insights into biosensing, bioimaging, genomics, diagnostics, and therapy. Chem Rev 114(12):6130–6178

    Article  CAS  PubMed  Google Scholar 

  • Yuan J, Tao Z, Yu Y, Ma X, Xia Y, Wang L, Wang Z (2014) A visual detection method for Salmonella typhimurium based on aptamer recognition and nanogold labeling. Food Control 37:188–192

    Article  CAS  Google Scholar 

  • Zhao S, Zhou Y, Wei L, Chen L (2020) Low fouling strategy of electrochemical biosensor based on chondroitin sulfate functionalized gold magnetic particle for voltammetric determination of Mycoplasma ovipneumonia in whole serum. Anal Chim Acta 1126:91–99

    Article  CAS  PubMed  Google Scholar 

  • Zhao S, Wen H, Ou Y, Li M, Wang L, Zhou H, Di B, Yu Z, Hu C (2021) A new design for living cell-based biosensors: microgels with a selectively permeable shell that can harbor bacterial species. Sens Actuators B Chem 334:129648

    Article  CAS  Google Scholar 

  • Zhu S, Fang Y (2017) Analysis of clinical etiology, serum type and drug resistance of lung cancer complicated with pulmonary haemophilus influenzae infection. China Pharm 28(17):2346–2350

    Google Scholar 

Download references

Acknowledgements

This review study was supported by the Aging Institute of Tabriz University of Medical Sciences, Iran.

Author information

Author notes

  1. Ahmad Mobed and Shirin Malehmir have contributed equally to this work.

Authors and Affiliations

  1. Physical Medicine and Rehabilitation Research Center, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran

    Ahmad Mobed

  2. Research Center of Psychiatry and Behavioral Science, Tabriz University of Medical Sciences, Tabriz, Iran

    Ahmad Mobed & Ali Ahmad alipour

  3. Karaj Branch, Molecular Biology Research Center, Islamic Azad University, Tehran, Iran

    Shirin Malehmir, Yasaman Azizimoghaddam & Hediyeh Saghi Sarabi

  4. Research Institute for Gastroenterology and Liver Diseases, Shaheed Beheshti University of Medical Sciences, Tehran, Iran

    Shirin Malehmir, Yasaman Azizimoghaddam & Hediyeh Saghi Sarabi

  5. Islamic Azad University of Pharmaceutical Sciences Branch, Tehran, Iran

    Ahmad Mobed, Yasaman Azizimoghaddam, Hediyeh Saghi Sarabi & Farhood Ghazi

  6. Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, 5154853431, Iran

    Farhood Ghazi

Authors
  1. Ahmad Mobed
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Shirin Malehmir
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ali Ahmad alipour
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yasaman Azizimoghaddam
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Hediyeh Saghi Sarabi
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Farhood Ghazi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ahmad Mobed.

Ethics declarations

Conflict of interest

There is no conflict of interest.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Mobed, A., Malehmir, S., Ahmad alipour, A. et al. Biosensors, modern technology for the detection of cancer-associated bacteria. Biotechnol Lett 44, 683–701 (2022). https://doi.org/10.1007/s10529-022-03257-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10529-022-03257-8

Keywords

Search

Navigation