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Physiological activities of a β-glucan produced by Panebacillus polymyxa

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Abstract

In vitro bioactivities of a β-glucan produced by Panebacillus polymyxa JB115 were investigated. Nitric oxide production by RAW 264.7 macrophage cells pre-treated with β-glucan JB115 (from 0.1 to 1 mg ml−1) was significantly increased, compared to that in untreated cells (P < 0.001). The β-glucan JB115 increased superoxide radical-scavenging activity by 66% at 1 mg ml−1. It also suppressed hyaluronidase (32%) and collagenase (33%) activities and, additionally, displayed antitumor activity, blocking the growth of Sarcoma 180 cells in a concentration-dependent manner. The immune-stimulatory, antioxidant, collagenase inhibitory and hyaluronidase inhibitory effects of the β-glucan support its potential role in the prevention of bacterial disease against fish and in the protection of skin against aging.

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Authors and Affiliations

  1. Bio Industry Center, Daegu New Technology Agency, Daegu, 704-801, Republic of Korea

    Hee-Kyoung Jung & Joo-Heon Hong

  2. College of Veterinary Medicine, Kyungpook National University, Daegu, 702-701, Republic of Korea

    Seung-Chun Park

  3. JEONJINBIO, Hosan-Dong, Dalseo-Gu, Daegu, 704-948, Republic of Korea

    Byung-Kwon Park

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  1. Hee-Kyoung Jung
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  2. Seung-Chun Park
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  4. Joo-Heon Hong
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Correspondence to Joo-Heon Hong.

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Jung, HK., Park, SC., Park, BK. et al. Physiological activities of a β-glucan produced by Panebacillus polymyxa . Biotechnol Lett 30, 1545–1551 (2008). https://doi.org/10.1007/s10529-008-9732-3

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  • DOI: https://doi.org/10.1007/s10529-008-9732-3

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