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Plasminogen Activator Inhibitor-1 Polymorphisms and Risk of Coronary Artery Disease: Evidence From Meta-Analysis and Trial Sequential Analysis

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Abstract

A systematic review and meta-analysis were conducted to find out if there was association between Plasminogen Activator Inhibitor-1 (PAI-1) gene polymorphisms (− 844 G > A and − 675 4G > 5G) and susceptibility to coronary artery disease (CAD). Search of electronic databases was performed and the pooled odds ratio (OR) and 95% confidence interval (CI) were exerted to evaluate the pooled association between the single-nucleotide polymorphisms (SNPs) and risk of CAD. For − 675 4G > 5G SNP, dominant (OR = 0.90), recessive (OR = 0.90), allelic (OR = 0.91), homozygous (OR = 0.84), and heterozygous (OR = 0.96) models were significantly associated with decreased risk of CAD. Moreover, all five genetic models were associated significantly with decreased CAD risk in the Causation and Arab populations. The results in Asians were marginally significant in recessive, allelic, and homozygote models. The male gender was found to be a risk factor in individuals with PAI-1 4G > 5G SNP in the dominant model (OR = 0.89), recessive model (OR = 0.91), allelic model (OR = 0.92), homozygous model (OR = 0.86), and heterozygous model (OR = 0.91). The results of pooled ORs for overall populations and subgroup analysis by ethnicity reject any association between PAI-1 gene − 844 G > A polymorphism and CAD risk under all genetic comparisons. The results of this meta-analysis indicated that PAI-1 4G > 5G SNP was associated with decreased risk of CAD in the overall population as well as in the Asians, Caucasians, and Arab populations. However, the PAI-1 gene − 844 G > A polymorphism had no significant association with susceptibility to CAD.

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Change history

  • 12 October 2023

    The original online version of this article was revised: The affiliation of the author Seyedeh Samaneh Tabaee has been corrected.

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Acknowledgements

The authors are grateful of Deputy of Research from Neyshabur University of Medical Science.

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Authors and Affiliations

  1. Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

    Samira Tabaei

  2. Department of Infectious Disease, Faculty of Medical Sciences, Sari Branch, Islamic Azad University, Sari, Iran

    Melodi Omraninava

  3. Department of Genetics and Immunology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran

    Sahar Mehranfar

  4. Social Determinant of Health Research Center, Clinical Research Institute, Urmia University of Medical Sciences, Urmia, Iran

    Sahar Mehranfar

  5. Department of Immunology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran

    Morteza Motallebnezhad

  6. Noncommunicable Disease Research Center, Neyshabur University of Medical Sciences, Imam Khomeini Street, 9319116911, Neyshabur, Iran

    Seyedeh Samaneh Tabaee

  7. Faculty of Medicine, Neyshabur University of Medical Sciences, Neyshabur, Iran

    Seyedeh Samaneh Tabaee

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Tabaei, S., Omraninava, M., Mehranfar, S. et al. Plasminogen Activator Inhibitor-1 Polymorphisms and Risk of Coronary Artery Disease: Evidence From Meta-Analysis and Trial Sequential Analysis. Biochem Genet 60, 1409–1445 (2022). https://doi.org/10.1007/s10528-021-10143-x

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  • DOI: https://doi.org/10.1007/s10528-021-10143-x

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