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Tumor Necrosis Factor Alpha and Interleukin 10 Promoter Polymorphisms in Mexican Patients with Restenosis After Coronary Stenting

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Abstract

To test for an association with risk for restenosis after coronary stent placement, the TNF-α and IL-10 polymorphisms were analyzed by 5′ exonuclease TaqMan assays in 162 patients who initially underwent coronary stenting. Analysis of basal and procedure coronary angiographies revealed a higher proportion of restenosis in lesions treated with bare metal stents compared with those treated with drug-eluting stents (P < 0.001). Distribution of TNF-α genotypes was similar in patients with and without restenosis. The IL-10 polymorphisms showed a moderate protective trend of the −819 TT genotype against restenosis when the lesions were analyzed (P = 0.071, OR = 0.471). Multivariate analysis confirmed a protective role for drug-eluting stents (P < 0.001, OR = 0.199) and the −819 TT genotype (P = 0.037, OR = 0.391). These results suggest the IL-10 −819 TT genotype has a protective role against in-stent restenosis.

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Acknowledgments

This study was supported in part by grants from the Consejo Nacional de Ciencia y Tecnología (Grant 50352-M/24147) and Fundación Gonzalo Rios Arronte, Mexico City, Mexico. The authors are grateful to the study participants. Institutional Review Board approval was obtained for all sample collections. We would like to thank Selene Inés-Real and Silvestre Ramírez-Fuentes for technical assistance.

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Authors and Affiliations

  1. Interventional Cardiology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico

    Marco Antonio Martínez-Ríos, Marco Antonio Peña-Duque, Hilda Delgadillo-Rodríguez, Emma Miranda-Malpica & Luis Gerardo Rodríguez-Lobato

  2. Department of Molecular Biology, Cardiovascular Disease Genomic and Proteomic Study Group, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano No. 1, Tlalpan, 14080, Mexico, D.F., Mexico

    José Manuel Fragoso, José Manuel Rodríguez-Pérez, David Cruz-Robles, María Magdalena Cavazos-Quero & Gilberto Vargas-Alarcón

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  1. Marco Antonio Martínez-Ríos
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  2. Marco Antonio Peña-Duque
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  3. José Manuel Fragoso
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  4. Hilda Delgadillo-Rodríguez
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  5. José Manuel Rodríguez-Pérez
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  6. Emma Miranda-Malpica
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  7. David Cruz-Robles
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  8. María Magdalena Cavazos-Quero
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  9. Luis Gerardo Rodríguez-Lobato
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  10. Gilberto Vargas-Alarcón
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Correspondence to Gilberto Vargas-Alarcón.

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Marco Antonio Martínez-Ríos and Marco Antonio Peña-Duque contributed equally to this work.

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Martínez-Ríos, M.A., Peña-Duque, M.A., Fragoso, J.M. et al. Tumor Necrosis Factor Alpha and Interleukin 10 Promoter Polymorphisms in Mexican Patients with Restenosis After Coronary Stenting. Biochem Genet 47, 707–716 (2009). https://doi.org/10.1007/s10528-009-9268-9

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  • DOI: https://doi.org/10.1007/s10528-009-9268-9

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