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Uridine Administration Promotes Normalization of Heart Mitochondrial Function in Dystrophin-Deficient Mice and Decreases Tissue Fibrosis

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The work shows the effect of the metabolic modulator uridine on the functioning and ultrastructure of heart mitochondria in dystrophin-deficient mdx mice. Intraperitoneal administration of uridine (30 mg/kg/day for 28 days) improved K+ transport and increased its content in the heart mitochondria of mdx mice to the level of wild-type animals. This was accompanied by a significant decrease in the level of malondialdehyde and an increase in the number of mitochondria in the heart of mdx mice. At the same time, uridine did not affect the hyperfunctionality of mitochondria in mdx mice, which manifested in an increase in the calcium retention capacity. Nevertheless, we noted that uridine causes a significant decrease in the level of fibrosis in the heart of mdx mice, which attested to a positive effect of therapy.

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Authors and Affiliations

  1. Mari State University, Yoshkar-Ola, Mari El Republic, Russia

    M. V. Dubinin, Yu. A. Chelyadnikova, D. K. Penkina, A. B. Vafina & K. N. Belosludtsev

  2. Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow region, Russia

    N. V. Belosludtseva, I. B. Mikheeva, V. S. Starinets & K. N. Belosludtsev

  3. A. N. Belozersky Institute of Physico-Chemical Biology, M. V. Lomonosov Moscow State University, Moscow, Russia

    I. I. Kireev

Authors
  1. M. V. Dubinin
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  2. N. V. Belosludtseva
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  3. I. B. Mikheeva
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  4. Yu. A. Chelyadnikova
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  5. D. K. Penkina
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  6. A. B. Vafina
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  7. V. S. Starinets
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  8. I. I. Kireev
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  9. K. N. Belosludtsev
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Corresponding author

Correspondence to M. V. Dubinin.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 176, No. 7, pp. 65-70, July, 2023

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Dubinin, M.V., Belosludtseva, N.V., Mikheeva, I.B. et al. Uridine Administration Promotes Normalization of Heart Mitochondrial Function in Dystrophin-Deficient Mice and Decreases Tissue Fibrosis. Bull Exp Biol Med 176, 54–59 (2023). https://doi.org/10.1007/s10517-023-05966-0

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  • DOI: https://doi.org/10.1007/s10517-023-05966-0

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