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Length of Leukocyte Telomeres in Newborns of HIV-Infected Mothers

  • ECOLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

We studied the relative length of telomeres in newborns with unrealized perinatal transmission of HIV (zero viral load according to PCR results). A cross-sectional survey of 62 newborns of HIV-infected mothers (Apgar score 8); the control group consisted of 80 healthy newborns (Apgar score 8). DNA extracted from whole venous blood samples was analyzed. In newborns of HIV-infected mothers, the relative length of telomeres was significantly lower (0.69 (0.66; 0.72)) than in newborns of the control group (1.1 (0.97; 1.22)) (p<0.001). No significant differences in the relative length of telomeres were found between newborns of mothers with a viral load at the time of delivery and with undetectable viral load: 0.69 (0.66; 0.73) and 0.69 (0.63; 0.72). These findings indicate that HIV-infection in mothers or exposure to antiretroviral therapy has an impact on the relative telomere length in leukocytes of newborns.

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Authors and Affiliations

  1. Scientific Center for Family Health and Human Reproduction Problems, Irkutsk, Russia

    N. A. Kurashova, A. S. Vanyarkina, A. G. Petrova, L. V. Rychkova, S. I. Kolesnikov, M. A. Darenskaya, E. V. Moskaleva & L. I. Kolesnikova

  2. Irkutsk State University, Irkutsk, Russia

    L. I. Kolesnikova

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  1. N. A. Kurashova
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  2. A. S. Vanyarkina
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  3. A. G. Petrova
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  4. L. V. Rychkova
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  5. S. I. Kolesnikov
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  6. M. A. Darenskaya
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  7. E. V. Moskaleva
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  8. L. I. Kolesnikova
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Correspondence to N. A. Kurashova.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 175, No. 2, pp. 227-232, February, 2023

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Kurashova, N.A., Vanyarkina, A.S., Petrova, A.G. et al. Length of Leukocyte Telomeres in Newborns of HIV-Infected Mothers. Bull Exp Biol Med 175, 260–264 (2023). https://doi.org/10.1007/s10517-023-05846-7

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  • DOI: https://doi.org/10.1007/s10517-023-05846-7

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